Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.

Airway hyper-responsiveness (AHR) is a key characteristic of asthma that remains poorly understood. Tidal breathing and deep inspiration ordinarily cause rapid relaxation of airway smooth muscle(ASM) (as demonstrated via application of length fluctuations to tissue strips) and are therefore implicated in modulation of AHR, but in some cases (such as application of transmural pressure oscillations to isolated intact airways) this mechanism fails. Here we use a multiscale biomechanical model for intact airways, that incorporates strain-stiffening due to collagen recruitment and dynamic force generation by ASM cells, to show that the geometry of the airway, together with interplay between dynamic active and passive forces, give rise to large stress and compliance heterogeneities across the airway wall that are absent in tissue strips. We show further that these stress heterogeneities result in auxotonic loading conditions that are currently not replicated in tissue-strip experiments; stresses in the strip are similar to hoop stress only at the outer airway wall and are under- or over-estimates of stresses at the lumen. Taken together these results suggest that a previously underappreciated factor - stress heterogeneities within the airway wall and consequent ASM cellular response to this micromechanical environment - could contribute to AHR and should be explored further both theoretically and experimentally.

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from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20dBpov
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