A Genome-Wide Association Study in Caucasian Women suggests the involvement of HLA genes in the severity of facial solar lentigines
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
[image: cover.gif?v=1&s=a0725b146d9b460a56978fcd] Summary Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks on chromosome 6, exhibited a False Discovery Rate below 25% when looking for associations with the facial lentigine score. The first block, in the 6p22 region, corresponded to int... περισσότερα »
Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.* Oncotarget. 2016 Jun 13; Authors: Wu J, Du J, Fu X, Liu B, Cao H, Li T, Su T, Xu J, Tse AK, Yu ZL Abstract Icaritin (IT) is a flavonoid isolated from Herba Epimedii. In this study, we evaluated the anti-melanoma activities of IT, and determined its cytotoxic mechanism. We found that IT exerted cytotoxicity to melanoma cells. Furthermore, IT induced melanoma cell apoptosis, which was accompanied with PARP cleavage. Mechanistically, IT suppressed p-STAT3 (tyr705) level in parallel wi... περισσότερα »
Gaining Ground on a Cure Through Synergy: Combining Checkpoint Inhibitors with Cancer Vaccines.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Gaining Ground on a Cure Through Synergy: Combining Checkpoint Inhibitors with Cancer Vaccines.* Expert Rev Clin Immunol. 2016 Jun 20; Authors: Vreeland TJ, Clifton GT, Herbert GS, Hale DF, Jackson DO, Berry JS, Peoples GE Abstract INTRODUCTION: The approval of multiple checkpoint inhibitors (CPIs) for the treatment of advanced malignancies has sparked an explosion of research in the field of cancer immunotherapy. Despite the success of these medications, a large number of patients with advanced malignancy do not benefit from therapy. Early research indicates that a therapeutic ... περισσότερα »
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma.* Genet Mol Res. 2016;15(2) Authors: Ma YB, Song DW, Nie RH, Mu GY Abstract MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uveal melanoma. Using quantitative reverse transcription-polymerase chain reaction, we detected ... περισσότερα »
Orbital exenteration: The 10-year Massachusetts Eye and Ear Infirmary experience.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Orbital exenteration: The 10-year Massachusetts Eye and Ear Infirmary experience.* Orbit. 2016 Jun 20;:1-8 Authors: Nagendran ST, Lee NG, Fay A, Lefebvre DR, Sutula FC, Freitag SK Abstract The authors report their experience with orbital exenteration surgery at one academic institution over a 10-year period and review the literature. This retrospective cohort study monitored outcomes of all patients who underwent orbital exenteration surgery at Massachusetts Eye and Ear Infirmary between January 2003 and January 2013. Patients with no follow-up data or survival data were exclude... περισσότερα »
Dendritic cell vaccination in melanoma patients: from promising results to future perspectives.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Dendritic cell vaccination in melanoma patients: from promising results to future perspectives.* Hum Vaccin Immunother. 2016 Jun 20;:0 Authors: Boudewijns S, Bloemendal M, Gerritsen WR, de Vries IJ, Schreibelt G Abstract Dendritic cells (DCs) play an important role in the induction of antitumor immunity. Therefore, they are used as anti-cancer vaccines in clinical studies in various types of cancer. DC vaccines are generally well tolerated and able to induce antigen-specific T cell responses in melanoma patients. After DC vaccinations, functional tumor-specific T cells are more ... περισσότερα »
Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo.* Oncotarget. 2016 Jun 14; Authors: Posch C, Moslehi H, Sanlorenzo M, Green G, Vujic I, Panzer-Grümayer R, Rappersberger K, Ortiz-Urda S Abstract Mutations in the receptor tyrosine kinase c-KIT (KIT) are frequent oncogenic alterations in melanoma and are predominantly detected in tumors of acral, mucosal, and chronically sun-damaged skin. Research indicates that melanocytes with aberrant KIT signaling can be found in the distant periphery of the primar... περισσότερα »
Advances in the Management of Conjunctival Melanoma.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Advances in the Management of Conjunctival Melanoma.* Surv Ophthalmol. 2016 Jun 16; Authors: Vora GK, Demirci H, Marr B, Mruthyunjaya P PMID: 27321895 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/28KbMXK περισσότερα »
High dose rate brachytherapy with customized applicators for malignant facial skin lesions.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*High dose rate brachytherapy with customized applicators for malignant facial skin lesions.* Cancer Radiother. 2016 Jun 16; Authors: Jumeau R, Renard-Oldrini S, Courrech F, Buchheit I, Oldrini G, Vogin G, Peiffert D Abstract PURPOSE: Brachytherapy is a well-known treatment in the management of skin tumors. For facial or scalp lesions, applicators have been developed to deliver non-invasive treatment. We present cases treated with customized applicators with high dose rate system. MATERIAL AND METHODS: Patients with poor performance status treated for malignant skin lesions of th... περισσότερα »
USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.* Oncogene. 2016 Jun 20; Authors: Jeong M, Lee EW, Seong D, Seo J, Kim JH, Grootjans S, Kim SY, Vandenabeele P, Song J Abstract FLICE-like inhibitory protein (FLIP) is a critical regulator of death receptor-mediated apoptosis. Here, we found ubiquitin-specific peptidase 8 (USP8) to be a novel deubiquitylase of the long isoform of FLIP (FLIPL). USP8 directly deubiquitylates and stabilizes FLIPL, but not the short isoform. USP8 depletion induces FLIPL destabilization, promoting anti-Fas-, tumor necrosi... περισσότερα »
Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib.* Oncogene. 2016 Jun 20; Authors: Doudican NA, Orlow SJ Abstract Activating BRAF mutations promote constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway and are common in a variety of human malignancies, including melanoma and colon cancer. Several small molecule BRAF inhibitors such as vemurafenib have been developed and demonstrate remarkable clinical efficacy. However, resistance typically emerges in most melanoma patients. Studies have demonstrat... περισσότερα »
An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome.* Vet Microbiol. 2016 Jun 4; Authors: Dawson HD, Smith AD, Chen C, Urban JF Abstract Emerging evidence suggests that swine are a scientifically acceptable intermediate species between rodents and humans to model immune function relevant to humans. The swine genome has recently been sequenced and several preliminary structural and functional analysis of the porcine immunome have been published. Herein we provide an expanded in silico analysis using an improved ... περισσότερα »
BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.* Cell Rep. 2016 Jun 16; Authors: Kemper K, Krijgsman O, Kong X, Cornelissen-Steijger P, Shahrabi A, Weeber F, van der Velden DL, Bleijerveld OB, Kuilman T, Kluin RJ, Sun C, Voest EE, Ju YS, Schumacher TN, Altelaar AF, McDermott U, Adams DJ, Blank CU, Haanen JB, Peeper DS Abstract The therapeutic landscape of melanoma is improving rapidly. Targeted inhibitors show promising results, but drug resistance often limits durable clinical responses. There is a need for in vivo sys... περισσότερα »
Suppression of inducible CD4 regulatory cells by MHC class I-restricted human tumor epitope specific TCR engineered multifunctional CD4 T Cells.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Suppression of inducible CD4 regulatory cells by MHC class I-restricted human tumor epitope specific TCR engineered multifunctional CD4 T Cells.* Hum Immunol. 2016 Jun 16; Authors: Chhabra A, Mukherji B Abstract Regulatory T cells (Treg) can interfere with the generation and function of anti-tumor immune effectors. Accordingly, ways that could block Treg function would be useful in cancer immunotherapy. We have previously shown that incorporation of CD4+CD25-ve T cells in an in vitro cytolytic T lymphocyte (CTL) generation assay leads to generation of induced regulatory T cells ... περισσότερα »
Society Information.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Society Information.* Pigment Cell Melanoma Res. 2016 Jul;29(4):484 Authors: PMID: 27320441 [PubMed - in process] from Melanoma via xlomafota13 on Inoreader http://ift.tt/28KbLmJ περισσότερα »
The melanoma field with dendritic roots.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*The melanoma field with dendritic roots.* Pigment Cell Melanoma Res. 2016 Jul;29(4):397 Authors: Aplin AE PMID: 27320440 [PubMed - in process] from Melanoma via xlomafota13 on Inoreader http://ift.tt/28MFteA περισσότερα »
The study of nevi in children: Principles learned and implications for melanoma diagnosis.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*The study of nevi in children: Principles learned and implications for melanoma diagnosis.* J Am Acad Dermatol. 2016 Jun 16; Authors: Scope A, Marchetti MA, Marghoob AA, Dusza SW, Geller AC, Satagopan JM, Weinstock MA, Berwick M, Halpern AC Abstract Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of t... περισσότερα »
[Adaptive drug licensing: A chance for patients?]
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*[Adaptive drug licensing: A chance for patients?]* Z Evid Fortbild Qual Gesundhwes. 2016;112 Suppl 1:S27-S33 Authors: Paar WD Abstract In recent years, various options have been discussed to accelerate the approval of new drugs, especially for conditions with high unmet needs. There is a trade-off between the earlier availability of new treatment options and a potentially higher safety risk of drugs which have not been investigated in long-lasting clinical trials and a broader patient population. It must also be taken into account that clinical trial data and results must be suf... περισσότερα »
Blitz Nevus: A Clinical Simulator of Melanoma.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Blitz Nevus: A Clinical Simulator of Melanoma.* Skinmed. 2016;14(2):131-133 Authors: Alonso-Corral MJ, Ruiz-Villaverde R, Sánchez-Cano D, Pulido-Fernández F Abstract A 17-year-old adolescent girl attended our clinic for a scheduled review of her nevus lesions. She complained about a lesion on the posterior region of her neck, which she had noticed approximately 2 years before. Even though it had not caused any symptoms, its appearance had changed according to her parents. The patient's medical history, as well as that of her family's, was unremarkable. PMID: 27319960 [PubMed - ... περισσότερα »
Primary amelanotic leptomeningeal melanomatosis in a child: a rare but severe disease.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Primary amelanotic leptomeningeal melanomatosis in a child: a rare but severe disease.* World Neurosurg. 2016 Jun 16; Authors: Szathmari A, Perbet R, Hermier M, Di Rocco F, Frappaz D, Mottolese C Abstract Primary leptomeningeal melanomatosis (PLM) is a rare and aggressive form of non-metastatic invasion of leptomeninges by malignant melanocytic cells. Clinical presentation includes non-specific meningism with various forms of CSF circulation/absorption disorders leading to hydrocephalus. We illustrate the case of a 5 years old child with PLM without neurocutaneous melanosis (NC... περισσότερα »
Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
*Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy.* Int J Radiat Oncol Biol Phys. 2016 Apr 8; Authors: Ahmed KA, Caudell JJ, El-Haddad G, Berglund AE, Welsh EA, Yue B, Hoffe SE, Naghavi AO, Abuodeh YA, Frakes JM, Eschrich SA, Torres-Roca JF Abstract PURPOSE/OBJECTIVES: Evidence from the management of oligometastases with stereotactic body radiation therapy (SBRT) reveals differences in outcomes based on primary histology. We have previously identified a multigene e... περισσότερα »
Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment from a phase 3 registration trial.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
*Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment from a phase 3 registration trial.* Eur J Cancer. 2016 Jun 17;64:1-11 Authors: Bonner JA, Giralt J, Harari PM, Baselga J, Spencer S, Bell D, Raben D, Liu J, Schulten J, Ang KK, Rosenthal DI Abstract BACKGROUND: Mucositis and dysphagia are common adverse effects of radiotherapy (RT) treatment of locally advanced squamous cell cancer of the head and neck (LA-SCCHN). Chemotherapy added to RT increases surviv... περισσότερα »
Flexible endoscopic treatment of Zenker's diverticulum: thirteen years' experience in Spain.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
*Flexible endoscopic treatment of Zenker's diverticulum: thirteen years' experience in Spain.* Rev Esp Enferm Dig. 2016 Apr 8;108:297-303 Authors: de la Morena Madrigal EJ, Pérez Arellano E, Rodríguez García I Abstract INTRODUCTION: Flexible endoscopic treatment is one of the alternative approaches for the management of Zenker's diverticum. The present paper shows our short-term and long-term results with flexible endoscopic cricopharyngeal myotomy/septotomy. PATIENTS AND METHODS: A retrospective analysis of our experience in patients with Zenker's diverticulum treated using a fle... περισσότερα »
Risk and prognostic factors for pneumonia and choking amongst Parkinson's disease patients with dysphagia.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
*Risk and prognostic factors for pneumonia and choking amongst Parkinson's disease patients with dysphagia.* Parkinsonism Relat Disord. 2016 May 30; Authors: Goh KH, Acharyya S, Ng SY, Boo JP, Kooi AH, Ng HL, Li W, Tay KY, Au WL, Tan LC Abstract OBJECTIVE: To evaluate the time to hospitalisation and baseline factors associated with pneumonia/choking in Parkinson's Disease (PD) patients. BACKGROUND: Although dysphagia and pneumonia are common problems in PD, scarce research has been performed. METHODS: A total of 194 PD patients who underwent a VFS evaluation were retrospectively s... περισσότερα »
Association Between Protein Intake, Occlusal Force, and Walking Speed in Older Adults.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
*Association Between Protein Intake, Occlusal Force, and Walking Speed in Older Adults.* J Am Geriatr Soc. 2016 Jun;64(6):1381-2 Authors: Saino Y, Wakabayashi H, Maeda K PMID: 27321635 [PubMed - in process] from #ENT via xlomafota13 on Inoreader http://ift.tt/28KEkmb via IFTTT περισσότερα »
Are esophagrams indicated in pediatric patients with spontaneous pneumomediastinum?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
*Are esophagrams indicated in pediatric patients with spontaneous pneumomediastinum?* J Pediatr Surg. 2016 Jun 6; Authors: Richer EJ, Sanchez R Abstract BACKGROUND/PURPOSE: Spontaneous pneumomediastinum is an infrequent condition in pediatric patients. Presenting symptoms include chest pain, dysphagia, or vomiting, without initiating event. Patients may undergo esophagram because of concern for esophageal perforation as the source for pneumomediastinum, however, abnormalities are rarely demonstrated. The objective of this study is to identify whether esophagrams performed on ped... περισσότερα »
A possible pathological link among swallowing dysfunction, gastro-esophageal reflex, and sleep apnea in acute exacerbation in COPD patients.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *A possible pathological link among swallowing dysfunction, gastro-esophageal reflex, and sleep apnea in acute exacerbation in COPD patients.* Int J Chron Obstruct Pulmon Dis. 2016;11:147-50 Authors: Teramoto S PMID: 26869780 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/28KElqB via IFTTT περισσότερα »
CX3CR1-dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
CX3CR1-dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation: Abstract CX3CR1-deficient mice develop very severe experimental autoimmune encephalomyelitis (EAE), associated with impaired NK cell recruitment into the CNS. Yet, the precise implications of NK cells in autoimmune neuroinflammation remain elusive. Here, we investigated the pattern of NK cell […] περισσότερα »
Relationship Among Signal Fidelity, Hearing Loss, and Working Memory for Digital Noise Suppression.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Authors: Arehart K, Souza P, Kates J, Lunner T, Pedersen MS Abstract OBJECTIVES: This study considered speech modified by additive babble combined with noise-suppression processing. The purpose was to determine the relative importance of the signal modifications, individual peripheral hearing loss, and individual cognitive capacity on speech intelligibility and speech quality. DESIGN: The participant group […] περισσότερα »
in Picture Naming
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Early and Late Electrophysiological Effects of Distractor Frequency in Picture Naming: Reconciling Input and Output Accounts.: J Cogn Neurosci. 2015 ; Authors: Riès SK, Fraser D, McMahon KL, de Zubicaray GI Abstract The «distractor-frequency effect» refers to the finding that high-frequency (HF) distractor words slow picture naming less than low-frequency distractors in the picture-word interference […] περισσότερα »
Sphincterplasty for Velopharyngeal Insufficiency in the Child Without a Cleft-Palate: Etiologies and Speech Outcomes.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Authors: Golinko MS, Mason K, Nett K, Riski JE, Williams JK Abstract The aim of this study is to report on speech outcomes following surgery for velopharyngeal insufficiency (VPI) on a broad spectrum of patients without a cleft palate. Inclusion criteria included patients without a cleft palate operated on by a single surgeon (JKW) […] περισσότερα »
Using ultrasound tongue imaging to identify covert contrasts in children's speech.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Using ultrasound tongue imaging to identify covert contrasts in children's speech.: Clin Linguist Phon. 2016 Jun 20;:1-14 Authors: Zharkova N, Gibbon FE, Lee A Abstract Ultrasound tongue imaging has become a promising technique for detecting covert contrasts, due to the developments in data analysis methods that allow for processing information on tongue shape from young […] περισσότερα »
Evaluation of the otolith function using c/oVEMPs in patients with Ménière's disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Evaluation of the otolith function using c/oVEMPs in patients with Ménière's disease: Abstract Background Cervical and ocular vestibular evoked myogenic potentials (c/oVEMPs) reflect otolith function. Up-to-date, there are no published reports on the systemic evaluation of otolith function in Ménière's Disease (MD) nor are there any reports on the differences in VEMPs between patients with […] περισσότερα »
Triester glycerol oxide on wound repair
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
An experimental study on the comparison of the effects of triester glycerol oxide on wound repair: Abstract Aim The aim of this study is to assess the effects of triester glycerol oxide (TGO) on cutaneous wound epithelization process. Material and methods Fifty-four male Wistar rats were divided into 2 groups of 27 rats each: control(C) […] περισσότερα »
Decoding human swallowing via electroencephalography: a state-of-the-art review.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Authors: Jestrović I, Coyle JL, Sejdić E Abstract Swallowing and swallowing disorders have garnered continuing interest over the past several decades. Electroencephalography (EEG) is an inexpensive and non-invasive procedure with very high temporal resolution which enables analysis of short and fast swallowing events, as well as an analysis of the organizational and behavioral aspects of […] περισσότερα »
Associations of Circulating Gut Hormone and Adipocytokine Levels with the Spectrum of Gastroesophageal Reflux Disease.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Authors: Tseng PH, Yang WS, Liou JM, Lee YC, Wang HP, Lin JT, Wu MS Abstract OBJECTIVE: The pathogenesis of gastroesophageal reflux disease (GERD) is complex and poorly understood. We aim to investigate the association of various circulating peptide hormones with heterogenous manifestations of GERD. METHODS: One hundred and four patients that had experienced typical […] περισσότερα »
Percutaneous endoscopic gastrostomy versus percutaneous radiological gastrostomy for swallowing disturbances.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Cochrane Database Syst Rev. 2016;2:CD009198 Authors: Yuan Y, Zhao Y, Xie T, Hu Y Abstract BACKGROUND: Gastrostomy has been established as the standard procedure for administering long-term enteral nutrition in individuals with swallowing disturbances. Percutaneous gastrostomy is a less-invasive approach than open surgical gastrostomy, and can be accomplished via endoscopy (percutaneous endoscopic gastrostomy or PEG) […] περισσότερα »
Assessing chronic stroke survivors with aphasia sheds light on prevalence of spatial neglect.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
*Assessing chronic stroke survivors with aphasia sheds light on prevalence of spatial neglect.* Top Stroke Rehabil. 2016 Jun 20;:1-8 Authors: Hreha K, Mulry C, Gross M, Jedziniak T, Gramas N, Ohevshalom L, Sheridan A, Szabo G, Davison C, Barrett AM Abstract BACKGROUND: Stroke is a chronic disease. Standardized assessment is essential in order to determine areas for treatment. Individuals with aphasia are often excluded from research, because it is believed that their language impairments may impact their ability to provide informed consent. Thus, right spatial neglect could be un... περισσότερα »
Using ultrasound tongue imaging to identify covert contrasts in children's speech.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
*Using ultrasound tongue imaging to identify covert contrasts in children's speech.* Clin Linguist Phon. 2016 Jun 20;:1-14 Authors: Zharkova N, Gibbon FE, Lee A Abstract Ultrasound tongue imaging has become a promising technique for detecting covert contrasts, due to the developments in data analysis methods that allow for processing information on tongue shape from young children. An important feature concerning analyses of ultrasound data from children who are likely to produce covert contrasts is that the data are likely to be collected without head-to-transducer stabilisation... περισσότερα »
Sphincterplasty for Velopharyngeal Insufficiency in the Child Without a Cleft-Palate: Etiologies and Speech Outcomes.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Sphincterplasty for Velopharyngeal Insufficiency in the Child Without a Cleft-Palate: Etiologies and Speech Outcomes.* J Craniofac Surg. 2015 Oct;26(7):2067-71 Authors: Golinko MS, Mason K, Nett K, Riski JE, Williams JK Abstract The aim of this study is to report on speech outcomes following surgery for velopharyngeal insufficiency (VPI) on a broad spectrum of patients without a cleft palate. Inclusion criteria included patients without a cleft palate operated on by a single surgeon (JKW) over a 10-year period and ... περισσότερα »
Early and Late Electrophysiological Effects of Distractor Frequency in Picture Naming: Reconciling Input and Output Accounts.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
Related Articles *Early and Late Electrophysiological Effects of Distractor Frequency in Picture Naming: Reconciling Input and Output Accounts.* J Cogn Neurosci. 2015 Oct;27(10):1936-47 Authors: Riès SK, Fraser D, McMahon KL, de Zubicaray GI Abstract The "distractor-frequency effect" refers to the finding that high-frequency (HF) distractor words slow picture naming less than low-frequency distractors in the picture-word interference paradigm. Rival input and output accounts of this effect have been proposed. The former attributes the effect to attentional selection mechanisms ope... περισσότερα »
Relationship Among Signal Fidelity, Hearing Loss, and Working Memory for Digital Noise Suppression.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Relationship Among Signal Fidelity, Hearing Loss, and Working Memory for Digital Noise Suppression.* Ear Hear. 2015 Sep-Oct;36(5):505-16 Authors: Arehart K, Souza P, Kates J, Lunner T, Pedersen MS Abstract OBJECTIVES: This study considered speech modified by additive babble combined with noise-suppression processing. The purpose was to determine the relative importance of the signal modifications, individual peripheral hearing loss, and individual cognitive capacity on speech intelligibility and speech quality. DE... περισσότερα »
Temporal variability in sung productions of adolescents who stutter.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
*Temporal variability in sung productions of adolescents who stutter.* J Commun Disord. 2016 Jun 2;62:101-114 Authors: Falk S, Maslow E, Thum G, Hoole P Abstract Singing has long been used as a technique to enhance and reeducate temporal aspects of articulation in speech disorders. In the present study, differences in temporal structure of sung versus spoken speech were investigated in stuttering. In particular, the question was examined if singing helps to reduce VOT variability of voiceless plosives, which would indicate enhanced temporal coordination of oral and laryngeal proce... περισσότερα »
Pregnancy in Spanish elite sportswomen: A qualitative research.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
*Pregnancy in Spanish elite sportswomen: A qualitative research.* Women Health. 2016 Jun 20; Authors: Martínez-Pascual B, Alvarez-Harris S, Fernández-de-Las-Peñas C, Palacios-Ceña D Abstract Pregnancy and motherhood have been historically considered as reasons why elite sportswomen may end their sport careers. During pregnancy the safety of both mother and baby has been identified as a key reason for ceasing sport participation. Recent "official" statistics on how many elite athletes are mothers suggest that pregnancy, motherhood and sport could be no longer mutually exclusive. T... περισσότερα »
Sphincterplasty for Velopharyngeal Insufficiency in the Child Without a Cleft-Palate: Etiologies and Speech Outcomes.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Sphincterplasty for Velopharyngeal Insufficiency in the Child Without a Cleft-Palate: Etiologies and Speech Outcomes.* J Craniofac Surg. 2015 Oct;26(7):2067-71 Authors: Golinko MS, Mason K, Nett K, Riski JE, Williams JK Abstract The aim of this study is to report on speech outcomes following surgery for velopharyngeal insufficiency (VPI) on a broad spectrum of patients without a cleft palate. Inclusion criteria included patients without a cleft palate operated on by a single surgeon (JKW) over a 10-year period and ... περισσότερα »
Effect of injection augmentation on need for framework surgery in unilateral vocal fold paralysis.
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 19 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Effect of injection augmentation on need for framework surgery in unilateral vocal fold paralysis.* Laryngoscope. 2016 Jan;126(1):128-34 Authors: Francis DO, Williamson K, Hovis K, Gelbard A, Merati AL, Penson DF, Netterville JL, Garrett CG Abstract OBJECTIVES/HYPOTHESIS: To determine whether injection augmentation reduces the likelihood of ultimately needing definitive framework surgery in unilateral vocal fold paralysis (UVFP) patients. STUDY DESIGN: Retrospective cohort study. METHODS: All patients diagnosed wit... περισσότερα »
Toxins, Vol. 8, Pages 186: Identification of Pathogenic Fusarium spp. Causing Maize Ear Rot and Poten tial Mycotoxin Production in China
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Ear rot is a serious disease that affects maize yield and grain quality worldwide. The mycotoxins are often hazardous to humans and livestock. In samples collected in China between 2009 and 2014, Fusarium verticillioides and F. graminearum species complex were the dominant fungi causing ear rot. According to the TEF-1α gene sequence, F. graminearum species […] περισσότερα »
Thin section magnetic resonance diffusion-weighted imaging in the detection of acute infratentorial stroke
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Introduction Magnetic resonance diffusion-weighted imaging (DWI) is the most accurate technique available for demonstrating acute infarction; however, false-negative DWI is higher in the infratentorium due to the limited spatial resolution with conventional 5 mm DWI. The aim of this study was to compare 5 mm DWI with 3 mm DWI in the detection of […] περισσότερα »
Distinguishing liver haemangiomas from metastatic tumours using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced diffusion-weighted imaging at 1.5T MRI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Introduction The aim of this study to evaluate the effectiveness of enhanced diffusion-weighted imaging (DWI) for distinguishing liver haemangiomas from metastatic tumours (mets). Methods This study included 23 patients with 27 haemangiomas and 26 patients with 46 mets. Breath-holding diffusion-weighted imaging (DWI) (b-values of 0, 50, 100, 150, 200, 400 and 800 s/mm2) were […] περισσότερα »
Outcomes of cutaneous squamous cell carcinoma of the head and neck with parotid metastases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Introduction Cutaneous squamous cell carcinoma of the head and neck (cHNSCC) metastatic to the parotid has a moderate risk of recurrence despite multimodality treatment. Immunosuppression is associated with lower rates of long-term cure. Our aim was to review outcomes of current management in a tertiary centre with a view to targeting future strategies. Methods […] περισσότερα »
Acoustic radiation force impulse accuracy and the impact of hepatic steatosis on liver fibrosis staging
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Introduction The accuracy of Acoustic Radiation Force Impulse (ARFI) imaging has been validated in the setting of hepatitis C, however, the accuracy in the setting of fatty liver disease (FLD) has been less well-established. The aim of this study was to assess the accuracy of ARFI in the setting of hepatic steatosis. Methods Patients […] περισσότερα »
Inflammatory breast disease: A pictorial essay with radiological-pathological correlation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Summary Inflammatory conditions of the breast are an important group of diseases that can mimic breast carcinoma on clinical and radiological grounds. This pictorial essay presents the radiological and pathological features of some of these entities. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28KKKBK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […] περισσότερα »
Deutsche Version der Northoff Catatonia Rating Scale (NCRS-dv)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Zusammenfassung Zum klinischen Bild der Katatonie gehören neben eindrucksvollen motorischen Phänomenen wie Rigidität, Dyskinesien, Festination, Gegenhalten, Posieren, Katalepsie, Stereotypien und Manierismen auch affektive Symptome (Aggression, Angst, Affektverflachung, emotionale Labilität etc.) und Störungen des Verhaltens (Mutismus, Autismus, Mitgehen, Echolalie/Eochpraxie etc.). Obwohl im angloamerikanischen Raum insgesamt sieben Skalen zur Erfassung katatoner Symptome für den klinischen und wissenschaftlichen […] περισσότερα »
Green synthesis of gold and silver nanoparticles using gallic acid: catalytic activity and conversion yield toward the 4-nitrophenol reduction reaction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract In the present report, gallic acid was used as both a reducing and stabilizing agent to synthesize gold and silver nanoparticles. The synthesized gold and silver nanoparticles exhibited characteristic surface plasmon resonance bands at 536 and 392 nm, respectively. Nanoparticles that were approximately spherical in shape were observed in high-resolution transmission electron microscopy and […] περισσότερα »
Exploring the intellectual structure of nanoscience and nanotechnology: journal citation network analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Understanding the research trends and intellectual structure of nanoscience and nanotechnology (nano) is important for governments as well as researchers. This paper investigates the intellectual structure of nano field and explores its interdisciplinary characteristics through journal citation networks. The nano journal network, where 41 journals are nodes and citation among the journals are links, […] περισσότερα »
Changing the Personality of a Face : Perceived Big Two and Big Five Personality Factors Modeled in Real Photographs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
General, spontaneous evaluations of strangers based on their faces have been shown to reflect judgments of these persons' intention and ability to harm. These evaluations can be mapped onto a 2D space defined by the dimensions trustworthiness (intention) and dominance (ability). Here we go beyond general evaluations and focus on more specific personality judgments derived […] περισσότερα »
Pazopanib versus sunitinib for the treatment of metastatic renal cell carcinoma patients with poor-risk features
Alexandros G. SfakianakisστοΘεραπείαΠριν από 28 δευτερόλεπτα
Abstract Purpose With the exception of temsirolimus, clinical trials in metastatic renal cell carcinoma (mRCC) with poor-risk features are lacking. We previously showed that vascular endothelial growth factor receptor tyrosine kinase inhibitors are active and well tolerated by poor-risk group. This study evaluated and compared the efficacy and safety of pazopanib and sunitinib in this group. Methods We reviewed the medical records of all patients with mRCC who had received pazopanib or sunitinib at Asan Medical Center. We only assessed patients who had three or more poor-risk fea... περισσότερα »
An experimental study on the comparison of the effects of triester glycerol oxide on wound repair
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
AbstractAim The aim of this study is to assess the effects of triester glycerol oxide (TGO) on cutaneous wound epithelization process. Material and methods Fifty-four male Wistar rats were divided into 2 groups of 27 rats each: control(C) and TGO (PX). The groups have been divided into three subgroups which included nine rats each regarding the wound excision on the 3rd, 7th, and 10th days, respectively. The specimens were evaluated according to histological properties and hydroxyproline levels. Results Seventh day examination showed that PX and control groups present the same scor... περισσότερα »
Four-unit fixed dental prostheses replacing the maxillary incisors supported by two narrow-diameter implants – a five-year case series
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Abstract Objectives (1) To determine the survival rate of 10 four-unit fixed dental prostheses (FDPs) replacing the four maxillary incisors, supported by 20 narrow-diameter implants (NDIs), (2) to assess the incidence of mechanical and biological complications, and (3) to evaluate bone level changes longitudinally after final FDP insertion. Materials and methods Ten patients (six women, four men), mean age 49.4 ± 12.6 years, were treated with a four-unit anterior maxillary FDP (six screw-retained; four cemented). Biological parameters, eventual technical complications, radiographic... περισσότερα »
Randomized Clinical Trial of Maxillary Sinus Grafting using Deproteinized Porcine and Bovine Bone Mineral
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Abstract Background Demineralized porcine bone mineral (DPBM) was recently developed and commercially available in maxillary sinus grafting, in which demineralized bovine bone mineral (DBBM) was widely used. Objectives The present randomized controlled clinical trial aimed to compare histological bone quality and radiographic volume stability in maxillary sinuses grafted with DPBM and DBBM. Materials and Methods Twenty sinuses in 16 participants were enrolled and randomly allocated to control and test groups using sequentially numbered, sealed envelopes; laterally approached sinus ... περισσότερα »
Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Publication date: Available online 21 June 2016 Source:Brain Stimulation Author(s): Suzanne Babyar, Taiza Santos-Pontelli, Tenysson Lemos, Suleimy Mazin, Marom Bikson, Dennis Q. Truong, Dylan Edwards, Michael Reding from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/28L9QnV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα »
Intra-Subject Consistency and Reliability of Response Following 2mA Transcranial Direct Current Stimulation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Publication date: Available online 21 June 2016 Source:Brain Stimulation Author(s): Katherine Dyke, Soyoung Kim, Georgina M. Jackson, Stephen R. Jackson BackgroundTranscranial direct current stimulation (tDCS) is a popular non-invasive brain stimulation technique that has been shown to influence cortical excitability. While polarity specific effects have often been reported, this is not always the case, and […] περισσότερα »
Interaction between Helicobacter pylori and host genetic variants in gastric carcinogenesis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/28LQDzX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα »
Idelalisib for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/28Q5OHD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα »
An experimental study on the comparison of the effects of triester glycerol oxide on wound repair
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract Aim The aim of this study is to assess the effects of triester glycerol oxide (TGO) on cutaneous wound epithelization process. Material and methods Fifty-four male Wistar rats were divided into 2 groups of 27 rats each: control(C) and TGO (PX). The groups have been divided into three subgroups which included nine rats each […] περισσότερα »
Open source deformable image registration system for treatment planning and recurrence CT scans
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract Background Clinical application of deformable registration (DIR) of medical images remains limited due to sparse validation of DIR methods in specific situations, e. g. in case of cancer recurrences. In this study the accuracy of DIR for registration of planning CT (pCT) and recurrence CT (rCT) images of head and neck squamous cell carcinoma (HNSCC) […] περισσότερα »
Bringing Cancer Prevention Research Competencies to the Classroom
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract The field of cancer prevention incorporates research all along the spectrum from basic science studies at the laboratory bench to epidemiology, behavioral sciences, and clinical studies, with the convergence of evidence from these different approaches aimed at implementing public health interventions that reduce the burden of this disease. Due to the necessity of multiple […] περισσότερα »
Utility of a Referral Letter to Improve Comprehensibility of Cancer Patients in Palliative Care: a Single-Center Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract In spite of a referral letter as an important document for communicating between physicians, whether it could also be useful as a source of information for patients has not yet established. We included cancer patients in palliative care setting, all of whom completed a standardized questionnaire regarding their opinion concerning the utility of a […] περισσότερα »
A Preliminary Attempt to Profile Tympanometric Measures in Infants Using High Frequency Probe Tones
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract There is dearth of published data on high frequency tympanometric measures for infants in Indian context. Aim of present study was to profile Peak compensated static acoustic admittance (Ytm), Tympanometric peak pressure (TPP), Tympanometric width (TW) and Equivalent ear canal volume (Vea) in infants. Cross-sectional study on 50 infants with present TEOAEs and with […] περισσότερα »
Advanced abdominal imaging with dual energy CT is feasible without increasing radiation dose
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract Background Dual energy CT (DECT) has proven its potential in oncological imaging. Considering the repeated follow-up examinations, radiation dose should not exceed conventional single energy CT (SECT). Comparison studies on the same scanner with a large number of patients, considering patient geometries and image quality, and exploiting full potential of SECT dose reduction are […] περισσότερα »
Percutaneous endoscopic gastrostomy versus percutaneous radiological gastrostomy for swallowing disturbances.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Percutaneous endoscopic gastrostomy versus percutaneous radiological gastrostomy for swallowing disturbances.* Cochrane Database Syst Rev. 2016;2:CD009198 Authors: Yuan Y, Zhao Y, Xie T, Hu Y Abstract BACKGROUND: Gastrostomy has been established as the standard procedure for administering long-term enteral nutrition in individuals with swallowing disturbances. Percutaneous gastrostomy is a less-invasive approach than open surgical gastrostomy, and can be accomplished via endoscopy (percutaneous endoscopic gastros... περισσότερα »
Reply.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Reply.* Clin Gastroenterol Hepatol. 2016 Mar;14(3):481-2 Authors: Ravi K, Friesen L, Issaka R, Kahrilas PJ, Pandolfino JE PMID: 26689901 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/28KEoT1 via IFTTT περισσότερα »
Associations of Circulating Gut Hormone and Adipocytokine Levels with the Spectrum of Gastroesophageal Reflux Disease.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Associations of Circulating Gut Hormone and Adipocytokine Levels with the Spectrum of Gastroesophageal Reflux Disease.* PLoS One. 2015;10(10):e0141410 Authors: Tseng PH, Yang WS, Liou JM, Lee YC, Wang HP, Lin JT, Wu MS Abstract OBJECTIVE: The pathogenesis of gastroesophageal reflux disease (GERD) is complex and poorly understood. We aim to investigate the association of various circulating peptide hormones with heterogenous manifestations of GERD. METHODS: One hundred and four patients t... περισσότερα »
Minor Motility Defects? Perhaps, but What About a True "Functional" Assessment?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Minor Motility Defects? Perhaps, but What About a True "Functional" Assessment?* Clin Gastroenterol Hepatol. 2016 Mar;14(3):481 Authors: Castell DO, Tutuian R PMID: 26453954 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/28KEkTw via IFTTT περισσότερα »
Thailanstatin A disrupts disease by inhibiting DNA-editing machinery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Rice University scientists have synthesised a novel anti-cancer agent, Thailanstatin A, which was originally isolated from a bacterial species collected in Thailand. Thailanstatin A fights cancer by inhibiting the spliceosome, the machinery in the cell… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28OIKYH via IFTTT περισσότερα »
PI3K as a target in pancreatic neuroendocrine tumours
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge (IDIBELL), led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitor of the… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28LRDGj via IFTTT περισσότερα »
Et registrert behov
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Et landsdekkende kvalitetsregister kan gi oss oversikt over hvor mange barn og unge med synshemning det er og om alle får den hjelpen de trenger. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28LREdz via IFTTT περισσότερα »
Effects of Aeration Treatment on γ-Aminobutyric Acid Accumulation in Germinated Tartary Buckwheat (Fagopyrum tataricum)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
To explore the optimum condition of γ-aminobutyric acid (GABA) accumulation in germinated tartary buckwheat, effects of some factors including aeration treatment, physiological indexes, air flow rate, culture temperature, and pH value of cultivating solution under hypoxia on GABA in germinated tartary buckwheat were investigated. The results showed that the dark cultures with distilled water at […] περισσότερα »
Comparison of Survival Rates, Tumor Stages, and Localization in between Obese and Nonobese Patients with Gastric Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Purpose. In this study we tried to determine the association between body-mass index (BMI), survival rate, and the stage of tumor at the time of diagnosis in patients with gastric cancer. Methods. A total of 270 gastric cancer patients' hospital records were retrospectively evaluated. Patients were grouped according to their BMI at the time of […] περισσότερα »
Variation in Out-of-Hospital Cardiac Arrest Management
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Objective. To evaluate variation in airway management strategies in one suburban emergency medical services system treating patients experiencing out-of-hospital cardiac arrest (OHCA). Method. Retrospective chart review of all adult OHCA resuscitation during a 13-month period, specifically comparing airway management decisions. Results. Paramedics demonstrated considerable variation in their approaches to airway management. Approximately half of all […] περισσότερα »
Surgery in head and neck cancer: United Kingdom National Multidisciplinary Guidelines – ERRATUM.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Surgery in head and neck cancer: United Kingdom National Multidisciplinary Guidelines – ERRATUM. J Laryngol Otol. 2016 Jun 20;:1 Authors: Homer JJ PMID: 27321287 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28MG1kZ via IFTTT περισσότερα »
Interventions that cause weight loss and the impact on cardiovascular risk factors: a systematic review and meta-analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Summary Overweight and obesity increase the risks of diabetes and cardiovascular disease (CVD). This has been shown to be reversed with weight loss. A systematic review and meta-analysis were performed to determine the effect of weight loss in the primary prevention of CVD. PubMed, Embase and the Cochrane Library databases were searched electronically through to […] περισσότερα »
Sugammadex: A Review of Neuromuscular Blockade Reversal
Alexandros G. SfakianakisστοΘεραπείαΠριν από 54 δευτερόλεπτα
Abstract Sugammadex (Bridion®) is a modified γ-cyclodextrin that reverses the effect of the steroidal nondepolarizing neuromuscular blocking agents rocuronium and vecuronium. Intravenous sugammadex resulted in rapid, predictable recovery from moderate and deep neuromuscular blockade in patients undergoing surgery who received rocuronium or vecuronium. Recovery from moderate neuromuscular blockade was significantly faster with sugammadex 2 mg/kg than with neostigmine, and recovery from deep neuromuscular blockade was significantly faster with sugammadex 4 mg/kg than with neostigmin... περισσότερα »
Reply—Letter to the Editor: What to Do, and What Not to Do, When Diagnosing and Treating Breakthrough Cancer Pain (BTcP): Expert Opinion
Alexandros G. SfakianakisστοΘεραπείαΠριν από 54 δευτερόλεπτα
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/28L7zch περισσότερα »
Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss.* PLoS One. 2015;10(11):e0142154 Authors: Atik T, Onay H, Aykut A, Bademci G, Kirazli T, Tekin M, Ozkinay F Abstract Comprehensive genetic testing has the potential to become the standard of care for individuals with hearing loss. In this study, we investigated the genetic etiology of autosomal recessive nonsyndromic hearing loss (ARNSHL) in a Turkish cohort including individuals with c... περισσότερα »
Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family.* Int J Mol Med. 2015 Oct;36(4):1035-41 Authors: Zheng SL, Zhang HL, Lin ZL, Kang QY Abstract Usher syndrome (USH) is an autosomal recessive (AR) multi-sensory degenerative disorder leading to deaf-blindness. USH is clinically subdivided into three subclasses, and 10 genes have been identified thus far. Clinical and genetic heterogeneities in USH make a precise diagnosis difficult. A dominant‑like USH family in successive generations ... περισσότερα »
Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.* Ear Hear. 2015 Sep-Oct;36(5):567-73 Authors: Barker F, MacKenzie E, Elliott L, de Lusignan S Abstract OBJECTIVES: This review documented the range and nature of reported outcome measures in the context of adult auditory rehabilitative research. DESIGN: A scoping review conducted as a part of the development of a systematic review of the effect of interventions to improve hearing aid use. The aut... περισσότερα »
Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.* Ear Hear. 2015 Sep-Oct;36(5):567-73 Authors: Barker F, MacKenzie E, Elliott L, de Lusignan S Abstract OBJECTIVES: This review documented the range and nature of reported outcome measures in the context of adult auditory rehabilitative research. DESIGN: A scoping review conducted as a part of the development of a systematic review of the effect of interventions to improve hearing aid use. The aut... περισσότερα »
Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family. Int J Mol Med. 2015 Oct;36(4):1035-41 Authors: Zheng SL, Zhang HL, Lin ZL, Kang QY Abstract Usher syndrome (USH) is an autosomal recessive (AR) multi-sensory degenerative disorder leading to deaf-blindness. USH is clinically subdivided into three subclasses, and 10 genes have been identified thus far. […] περισσότερα »
Evaluation of the otolith function using c/oVEMPs in patients with Ménière's disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background Cervical and ocular vestibular evoked myogenic potentials (c/oVEMPs) reflect otolith function. Up-to-date, there are no published reports on the systemic evaluation of otolith function in Ménière's Disease (MD) nor are there any reports on the differences in VEMPs between patients with early and late stage MD. The aim of this study was to […] περισσότερα »
Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss. PLoS One. 2015;10(11):e0142154 Authors: Atik T, Onay H, Aykut A, Bademci G, Kirazli T, Tekin M, Ozkinay F Abstract Comprehensive genetic testing has the potential to become the standard of care for individuals with hearing loss. In this study, we […] περισσότερα »
Focal liver hyperplasia in a patient with Alagille syndrome: Diagnostic difficulties. A case report.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Focal liver hyperplasia in a patient with Alagille syndrome: Diagnostic difficulties. A case report.* Int J Surg Case Rep. 2016 Jun 4;25:55-61 Authors: Ennaifer R, Ben Farhat L, Cheikh M, Romdhane H, Marzouk I, Belhadj N Abstract INTRODUCTION: Alagille syndrome is a multisystem autosomal disorder. The main clinical features are chronic cholestasis due to paucity of intrahepatic bile ducts, which can progress to cirrhosis and liver failure. PRESENTATION OF CASE: A 15 year-old girl with Alagille syndrome was referred for liver transplantation. She developed severe cirrhosis with r... περισσότερα »
Nerve distributions in insertional achilles tendinopathy - a comparison of bone, bursae and tendon.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Nerve distributions in insertional achilles tendinopathy - a comparison of bone, bursae and tendon.* Histol Histopathol. 2016 Jun 20;:11790 Authors: Andersson G, Backman LJ, Christensen J, Alfredson H Abstract BACKGROUND/AIM: In a condition of pain in the Achilles tendon insertion there are multiple structures involved, such as the Achilles tendon itself, the retrocalcaneal bursa and a bony protrusion at the calcaneal tuberosity called Haglund's deformity. The innervation patterns of these structures are scarcely described, and the subcutaneous calcaneal bursa is traditionally n... περισσότερα »
Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy.* Oncotarget. 2016 Jun 14; Authors: Wan X, Pu H, Huang W, Yang S, Zhang Y, Kong Z, Yang Z, Zhao P, Li A, Li T, Li Y Abstract The main challenge in the treatment of prostate cancer (PCa) is that the majority of patients inevitably develop resistance to androgen deprivation. However, the mechanisms involved in hormone independent behavior of PCa remain unclear. In the present study, we identified androgen-induced miR-135a as a direct ... περισσότερα »
Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model.* Oncotarget. 2016 Jun 13; Authors: Li YT, Liu CJ, Su TH, Cheng HR, Jeng YM, Lin HL, Wang CC, Kao JH, Chen PJ, Chen DS, Wu HL Abstract The metastatic tumor antigen 1 (MTA1) protein is associated with tumor invasiveness and poor prognosis in patients with hepatocellular carcinoma (HCC), particularly in those with hepatitis B virus (HBV)-related HCC. Chronically woodchuck hepatitis virus (WHV)-inf... περισσότερα »
Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.* Oncotarget. 2016 Jun 13; Authors: Wu J, Du J, Fu X, Liu B, Cao H, Li T, Su T, Xu J, Tse AK, Yu ZL Abstract Icaritin (IT) is a flavonoid isolated from Herba Epimedii. In this study, we evaluated the anti-melanoma activities of IT, and determined its cytotoxic mechanism. We found that IT exerted cytotoxicity to melanoma cells. Furthermore, IT induced melanoma cell apoptosis, which was accompanied with PARP cleavage. Mechanistically, IT suppressed p-STAT3 (tyr705) level in parallel wi... περισσότερα »
Prognostic value and their clinical implication of 89-gene signature in glioma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Prognostic value and their clinical implication of 89-gene signature in glioma.* Oncotarget. 2016 Jun 13; Authors: Shahid M, Cho KM, Nguyen MN, Choi TG, Jo YH, Aryal SN, Yoo JY, Yun HR, Lee JW, Eun YG, Lee JS, Kang I, Ha J, Yoon HJ, Kim SY, Kim SS Abstract Gliomas are the most common and aggressive primary tumors in adults. The current approaches, such as histological classification and molecular genetics, have limitation in prediction of individual therapeutic outcomes due to heterogeneity within the tumor groups. Recent studies have proposed several gene signatures to predict ... περισσότερα »
MiR-495 inhibits esophageal squamous cell carcinoma progression by targeting Akt1.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*MiR-495 inhibits esophageal squamous cell carcinoma progression by targeting Akt1.* Oncotarget. 2016 Jun 13; Authors: Mao Y, Li L, Liu J, Wang L, Zhou Y Abstract MicroRNAs are involved in tumor initiation and progression by regulating oncogenes and tumor suppressor genes. Here we found that miR-495 are lower in clinical ESCC tissues than in adjacent non-tumor tissues. Moreover, the lower miR-495 expression correlated with increased lymph node metastasis (LNM), invasion and TNM stage. miR-495 overexpression predicted a favorable outcome in ESCC patients. miR-495 targeted a site i... περισσότερα »
Fas ligand and lytic granule differentially control cytotoxic dynamics of Natural Killer cell against cancer target.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Fas ligand and lytic granule differentially control cytotoxic dynamics of Natural Killer cell against cancer target.* Oncotarget. 2016 Jun 13; Authors: Zhu Y, Huang B, Shi J Abstract Interaction dynamics between Natural Killer (NK) cells and cancer targets have been the topic of many previous investigations, but the underlying rate-limiting kinetics and heterogeneity remain poorly understood. In this study, using quantitative single cell microscopy assay, we elucidate the differential dynamic control of NK-cancer cell interaction by multiple cytotoxic pathways. We found primary ... περισσότερα »
The non-coding landscape of head and neck squamous cell carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*The non-coding landscape of head and neck squamous cell carcinoma.* Oncotarget. 2016 Jun 13; Authors: Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King CC, Lippman SM, Wang XQ, Hinton A, Ongkeko WM Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence and metastasis and stagnant survival rates. To enhance molecular knowledge of HNSCC and define a non-coding RNA (ncRNA) landscape of the disease, we profiled the transcriptome-wide dysregulation o... περισσότερα »
The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells.* Oncotarget. 2016 Jun 13; Authors: Ingangi V, Bifulco K, Yousif AM, Ragone C, Motti ML, Rea D, Minopoli M, Botti G, Scognamiglio G, Fazioli F, Gallo M, De Chiara A, Arra C, Grieco P, Carriero MV Abstract The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized master regulator of cell migration and uPAR88-92 is the minimal sequence required to induce cell motility and angiogenesis by interacting with the f... περισσότερα »
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.* Oncotarget. 2016 Jun 13; Authors: Cesnekova J, Spacilova J, Hansikova H, Houstek J, Zeman J, Stiburek L Abstract p53 is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of p53 into mitochondria where it acts to protect mitochondrial genome or trigger cell death via transcription-independent manner. Here we report that the mamm... περισσότερα »
Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice.* Oncotarget. 2016 Jun 13; Authors: Chen MC, Hsu WL, Hwang PA, Chen YL, Chou TC Abstract Cancer cachexia is characterized by anorexia, skeletal muscle atrophy, and systemic inflammation. Fucoidan extracted from brown algae exhibits anti-inflammatory and anticancer activities. However, whether fucoidan ameliorates tumour and chemotherapy-induced muscle atrophy and -related cachectic symptoms remains unknown. Compared with mice with bladder cancer ... περισσότερα »
Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.* Oncotarget. 2016 Jun 13; Authors: Matondo RB, Toussaint MJ, Govaert KM, van Vuuren LD, Nantasanti S, Nijkamp MW, Pandit SK, Tooten PC, Koster MH, Holleman K, Schot A, Gu G, Spee B, Roskams T, Rinkes IB, Schotanus B, Kranenburg O, de Bruin A Abstract The long term prognosis of liver cancer patients remains unsatisfactory because of cancer recurrence after surgical interventions, particularly in patients with viral infections. Since hepatitis B and C viral prote... περισσότερα »
Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.* Oncotarget. 2016 Jun 13; Authors: Yamanoi K, Matsumura N, Murphy SK, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Koshiyama M, Konishi I, Mandai M Abstract Anoikis resistance is a hallmark of cancer, and relates to malignant phenotypes, including chemoresistance, cancer stem like phenotypes and dissemination. The aim of this study was to identify key factors contributing to anoikis resistance in ovarian cancer using a functional ... περισσότερα »
iPhos-PseEn: Identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*iPhos-PseEn: Identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier.* Oncotarget. 2016 Jun 13; Authors: Qiu WR, Xiao X, Xu ZC, Chou KC Abstract Protein phosphorylation is a posttranslational modification (PTM or PTLM), where a phosphoryl group is added to the residue(s) of a protein molecule. The most commonly phosphorylated amino acids occur at serine (S), threonine (T), and tyrosine (Y). Protein phosphorylation plays a significant role in a wide range of cellular processes; meanwhile its dysregulation is also involved wi... περισσότερα »
FH535, a β-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*FH535, a β-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis.* Oncotarget. 2016 Jun 13; Authors: Liu L, Zhi Q, Shen M, Gong FR, Zhou BP, Lian L, Shen B, Chen K, Duan W, Wu MY, Tao M, Li W Abstract The WNT/β-catenin pathway plays an important role in pancreatic cancer carcinogenesis. We evaluated the correlation between aberrant β-catenin pathway activation and the prognosis pancreatic cancer, and the potential of applying the β-catenin pathway inhibitor FH535 to pancreatic cancer treatment. Meta-analysis and immunohistochemistry showed that... περισσότερα »
Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis.* Oncotarget. 2016 Jun 13; Authors: Jia Z, Zhuang Y, Hu C, Zhang X, Ding G, Zhang Y, Rohatgi R, Hua H, Huang S, He JC, Zhang A Abstract Imbalance of salt and water is a frequent and challenging complication of kidney disease, whose pathogenic mechanisms remain elusive. Employing an albumin overload mouse model, we discovered that albuminuria enhanced the expression of NHE3 and NCC but not other transporters in murine kidney in line with the stimulation of angiotensinogen (AGT)... περισσότερα »
Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.* Oncotarget. 2016 Jun 13; Authors: Pratheeshkumar P, Son YO, Divya SP, Turcios L, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Shi X Abstract Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with an increased risk of lung cancer. However, the mechanisms underlying Cr(VI)-induced carcinogenesis remain unclear. MicroRNA-21 (miR-21) is a key regulator of oncogenic processes. Studies have shown that... περισσότερα »
Impact of autoimmune diseases on outcome of patients with early breast cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Impact of autoimmune diseases on outcome of patients with early breast cancer.* Oncotarget. 2016 Jun 13; Authors: Criscitiello C, Bagnardi V, Esposito A, Gelao L, Santillo B, Viale G, Rotmensz N, Goldhirsch A, Curigliano G Abstract Our aim was to analyze the impact of a concurrent autoimmune disease on outcome of patients with early breast cancer. We reviewed medical charts of patients with a diagnosis of autoimmune diseases (AD) among a population of 17.153 cases. We categorized ADs as endocrine, rheumatic, systemic, neurological diseases and vasculitis. For each patient in the... περισσότερα »
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.* Oncotarget. 2016 Jun 13; Authors: Lopez S, Voisset E, Tisserand JC, Mosca C, Prebet T, Santamaria D, Dubreuil P, De Sepulveda P Abstract CDK4/CDK6 and RB proteins drive the progression through the G1 phase of the cell cycle. In acute myeloid leukemia (AML), the activity of the CDK/Cyclin D complex is increased. The mechanism involved is unknown, as are the respective roles played by CDK4 or CDK6 in this process. Here, we report that AML cells carrying FLT3-ITD mutations are dependent on CDK6 for cell ... περισσότερα »
Reduction of estradiol in human malignant pleural mesothelioma tissues may prevent tumour growth, as implied by in in-vivo and in-vitro models.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Reduction of estradiol in human malignant pleural mesothelioma tissues may prevent tumour growth, as implied by in in-vivo and in-vitro models.* Oncotarget. 2016 Jun 13; Authors: Nuvoli B, Sacconi A, Cortese G, Germoni S, Murer B, Galati R Abstract This study aimed to investigate intratumoural estradiol and estrogen-receptors (ERα, ERβ and GPR30) in malignant pleural mesothelioma (MPM) to understand their function. Here, we report that immunohistochemistry of estradiol showed cytoplasmatic staining in 95% of fifty-seven human MPM samples with a trend toward a negative correlation... περισσότερα »
GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.* Oncotarget. 2016 Jun 13; Authors: Lee S, Cho YE, Kim SH, Kim YJ, Park JH Abstract The alternative reading frame protein (p14ARF/ARF) is a key determinant of cell fate, acting as a potent tumor suppressor through a p53/MDM2-dependent pathway or promoting apoptosis in a p53-independent manner. The ARF protein is mainly expressed in the nucleolus and sequestered by nucleophosmin (NPM), whereas ARF-binding proteins, including p53 and MDM2, predominantly reside in the nucleoplasm. This rais... περισσότερα »
Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects.* Acta Otolaryngol. 2016 Jun 20;:1-4 Authors: Wada Y, Nishiike S, Kitahara T, Yamanaka T, Imai T, Ito T, Sato G, Matsuda K, Kitamura Y, Takeda N Abstract CONCLUSION: After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags in trials 3-8, it is suggested that the adaptation to repeated visual-vestibulosomatosensory conflict in the VR world improved dynam... περισσότερα »
Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base.* Braz J Otorhinolaryngol. 2016 May 31; Authors: Dolci RL, Miyake MM, Tateno DA, Cançado NA, Campos CA, Dos Santos AR, Lazarini PR Abstract INTRODUCTION: The large increase in the number of transnasal endoscopic skull base surgeries is a consequence of greater knowledge of the anatomic region, the development of specific materials and instruments, and especially the use of the nasoseptal flap as a barrier between the sinus tract (contaminated cavity) and the subarachnoid sp... περισσότερα »
Primary repair of open neural tube defect in adulthood: case example and review of management strategies.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary repair of open neural tube defect in adulthood: case example and review of management strategies.* Spine J. 2015 Nov 1;15(11):e57-63 Authors: Godzik J, Ravindra VM, Ray WZ, Eskandari R, Dailey AT Abstract BACKGROUND CONTEXT: Neural tube defects are congenital malformations that develop when the neural plate fails to close during embryogenesis. The most common open neural tube defect, myelomeningocele (MMC), is declining in frequency in North America. If identified, an MMC must be closed in the perinatal p... περισσότερα »
Right Internal Jugular Vein Cannulation: Carotid Artery-directed versus Sternocleidomastoid-directed Methods.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--images.ingentaselect.com-images-l] Related Articles *Right Internal Jugular Vein Cannulation: Carotid Artery-directed versus Sternocleidomastoid-directed Methods.* Am Surg. 2016 Feb;82(2):161-5 Authors: Yu ZY, Yuan P, Pan Y, Zhang ZM Abstract The aim of the present study was to explore a simple and safe method for central venous catheterization (CVC) from the right internal jugular vein (RIJV) by comparing carotid artery (CA) positioning with sternocleidomastoid (SCM) positioning. The medical records of patients who underwent CVC between January 2011 and January 20... περισσότερα »
Comparison of ultrasonography and surface landmarks in detecting the localization for cricothyroidotomy.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparison of ultrasonography and surface landmarks in detecting the localization for cricothyroidotomy.* Am J Emerg Med. 2016 Feb;34(2):254-6 Authors: Yıldız G, Göksu E, Şenfer A, Kaplan A Abstract OBJECTIVE: The aim of the study was to compare ultrasonography (US) and surface landmark techniques for detecting the cricothyroid membrane (CTM) to perform a cricothyroidotomy on healthy volunteers. METHODS: In this prospective observational study, 5 operators and 24 models were included. The borders of the CTM were m... περισσότερα »
Use of endotracheal tubes with subglottic secretion drainage reduces ventilator-associated pneumonia in trauma patients.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Use of endotracheal tubes with subglottic secretion drainage reduces ventilator-associated pneumonia in trauma patients.* J Trauma Acute Care Surg. 2016 Feb;80(2):218-22 Authors: Hubbard JL, Veneman WL, Dirks RC, Davis JW, Kaups KL Abstract BACKGROUND: Patients sustaining traumatic injuries have a higher incidence of ventilator-associated pneumonia (VAP) compared with other critically ill patient populations. Previous studies of patients with predominantly medical diagnoses and use of endotracheal tubes allowing s... περισσότερα »
Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy.* Cancer. 2016 Feb 15;122(4):546-58 Authors: Pan JJ, Ng WT, Zong JF, Chan LL, O'Sullivan B, Lin SJ, Sze HC, Chen YB, Choi HC, Guo QJ, Kan WK, Xiao YP, Wei X, Le QT, Glastonbury CM, Colevas AD, Weber RS, Shah JP, Lee AW Abstract BACKGROUND: An accurate staging system is crucial for cancer management. Evaluations for continual suitability and improvement are needed as staging and tre... περισσότερα »
An automatic method to detect and track the glottal gap from high speed videoendoscopic images.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *An automatic method to detect and track the glottal gap from high speed videoendoscopic images.* Biomed Eng Online. 2015;14:100 Authors: Andrade-Miranda G, Godino-Llorente JI, Moro-Velázquez L, Gómez-García JA Abstract BACKGROUND: The image-based analysis of the vocal folds vibration plays an important role in the diagnosis of voice disorders. The analysis is based not only on the direct observation of the video sequences, but also in an objective characterization of the phonation proce... περισσότερα »
Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: Functional outcomes.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: Functional outcomes.* Laryngoscope. 2016 Jan;126(1):118-21 Authors: Simpson CB, Lee CT, Hatcher JL, Michalek J Abstract OBJECTIVES/HYPOTHESIS: Supraglottic injection of botulinum toxin (Botox) has been described as an effective treatment for adductor spasmodic dysphonia (ADSD). Anecdotal evidence suggests that the patients have little to no breathiness after injection, but no formal longitudinal studies have been carried out to date. ... περισσότερα »
Cricopharyngeal dysfunction: A systematic review comparing outcomes of dilatation, botulinum toxin injection, and myotomy.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Cricopharyngeal dysfunction: A systematic review comparing outcomes of dilatation, botulinum toxin injection, and myotomy.* Laryngoscope. 2016 Jan;126(1):135-41 Authors: Kocdor P, Siegel ER, Tulunay-Ugur OE Abstract OBJECTIVES: Cricopharyngeal dysfunction may lead to severe dysphagia and aspiration. The objective of this systematic review was to evaluate the existing studies on the effectiveness of myotomy, dilatation, and botulinum toxin (BoT) injection in the management of cricopharyngeal dysphagia. METHODS: Pub... περισσότερα »
The effects of anesthesia and opioids on the upper airway: A systematic review.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The effects of anesthesia and opioids on the upper airway: A systematic review.* Laryngoscope. 2016 Jan;126(1):270-84 Authors: Ehsan Z, Mahmoud M, Shott SR, Amin RS, Ishman SL Abstract OBJECTIVES/HYPOTHESIS: Drug-induced sleep endoscopy (DISE) is used to determine surgical therapy for obstructive sleep apnea (OSA); however, the effects of anesthesia on the upper airway are poorly understood. Our aim was to systematically review existing literature on the effects of anesthetic agents on the upper airway. DATA SOUR... περισσότερα »
Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Whole-exome sequencing identifies USH2A mutations in a pseudo-dominant Usher syndrome family.* Int J Mol Med. 2015 Oct;36(4):1035-41 Authors: Zheng SL, Zhang HL, Lin ZL, Kang QY Abstract Usher syndrome (USH) is an autosomal recessive (AR) multi-sensory degenerative disorder leading to deaf-blindness. USH is clinically subdivided into three subclasses, and 10 genes have been identified thus far. Clinical and genetic heterogeneities in USH make a precise diagnosis difficult. A dominant‑like USH family in successive generations... περισσότερα »
Evaluation of the otolith function using c/oVEMPs in patients with Ménière's disease
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Background Cervical and ocular vestibular evoked myogenic potentials (c/oVEMPs) reflect otolith function. Up-to-date, there are no published reports on the systemic evaluation of otolith function in Ménière's Disease (MD) nor are there any reports on the differences in VEMPs between patients with early and late stage MD. The aim of this study was to evaluate the difference in c/oVEMPs between patients with MD and normal controls, as well as between patients with early and late stage MD. Methods Thirty patients with unilateral MD and thirty healthy subjects (as normal con... περισσότερα »
Decoding human swallowing via electroencephalography: a state-of-the-art review.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--ej.iop.org-icons-external-pubmed-] Related Articles *Decoding human swallowing via electroencephalography: a state-of-the-art review.* J Neural Eng. 2015 Oct;12(5):051001 Authors: Jestrović I, Coyle JL, Sejdić E Abstract Swallowing and swallowing disorders have garnered continuing interest over the past several decades. Electroencephalography (EEG) is an inexpensive and non-invasive procedure with very high temporal resolution which enables analysis of short and fast swallowing events, as well as an analysis of the organizational and behavioral aspects of cortical ... περισσότερα »
Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss.* PLoS One. 2015;10(11):e0142154 Authors: Atik T, Onay H, Aykut A, Bademci G, Kirazli T, Tekin M, Ozkinay F Abstract Comprehensive genetic testing has the potential to become the standard of care for individuals with hearing loss. In this study, we investigated the genetic etiology of autosomal recessive nonsyndromic hearing loss (ARNSHL) in a Turkish cohort including individuals with ... περισσότερα »
Changing the Personality of a Face : Perceived Big Two and Big Five Personality Factors Modeled in Real Photographs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
General, spontaneous evaluations of strangers based on their faces have been shown to reflect judgments of these persons' intention and ability to harm. These evaluations can be mapped onto a 2D space defined by the dimensions trustworthiness (intention) and dominance (ability). Here we go beyond general evaluations and focus on more specific personality judgments derived […] περισσότερα »
Bodies of truth : law, memory, and emancipation in post-apartheid South Africa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28LbBAw via IFTTT περισσότερα »
Indienliebe : die frühe Ethnographie und ihre Bilder
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28KHoxB via IFTTT περισσότερα »
Intraindividual long-term stability of sleep electroencephalography in school-aged children
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28Lbx47 via IFTTT περισσότερα »
Prevention of breast cancer by RANKL/RANK blockade
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Prevention of breast cancer by RANKL/RANK blockade Cell Research advance online publication, June 21 2016. doi:10.1038/cr.2016.79 Authors: Lorenzo Galluzzi, Aitziber Buqué & Guido Kroemer from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28KHiWV via IFTTT περισσότερα »
Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab Cell Research advance online publication, June 21 2016. doi:10.1038/cr.2016.77 Authors: Zhenkun Na, Siok Ping Yeo, Sakshibeedu R Bharath, Matthew W Bowler, Esra Balıkçı, Cheng-I Wang & Haiwei Song from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28LbyEU via IFTTT περισσότερα »
Cortical neurons gradually attain a post-mitotic state
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cortical neurons gradually attain a post-mitotic state Cell Research advance online publication, June 21 2016. doi:10.1038/cr.2016.76 Authors: Froylan Calderon de Anda, Ram Madabhushi, Damien Rei, Jia Meng, Johannes Gräff, Omer Durak, Konstantinos Meletis, Melanie Richter, Birgit Schwanke, Alison Mungenast & Li-Huei Tsai from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28KHm8Z via IFTTT περισσότερα »
Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8 Cell Research advance online publication, June 21 2016. doi:10.1038/cr.2016.78 Authors: Christina Helmke, Monika Raab, Franz Rödel, Yves Matthess, Thomas Oellerich, Ranadip Mandal, Mourad Sanhaji, Henning Urlaub, Claus Rödel, Sven Becker & Klaus Strebhardt from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28LbyoE via […] περισσότερα »
IJMS, Vol. 17, Pages 977: Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and […] περισσότερα »
IJMS, Vol. 17, Pages 975: Role of mTOR Inhibitors in Kidney Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The first compound that inhibited the mammalian target of rapamycin (mTOR), sirolimus (rapamycin) was discovered in the 1970s as a soil bacterium metabolite collected on Easter Island (Rapa Nui). Because sirolimus showed antiproliferative activity, researchers investigated its molecular target and identified the TOR1 and TOR2. The mTOR consists of mTOR complex 1 (mTORC1) and mTORC2. […] περισσότερα »
IJMS, Vol. 17, Pages 978: The Chlorophyll a Fluorescence Modulated by All-Trans-β-Carotene in the Process of Photos ystem II
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Modulating the chlorophyll a (Chl-a) fluorescence by all-trans-β-Carotene (β-Car) in the polarity and non-polarity solutions was investigated. The fluorescence intensity of Chl-a decreased as the concentration of β-Car increased. The excited electronic levels of Chl-a and β-Car became much closer owing to the solvent effect, which led to the electron transfer between both two molecules. […] περισσότερα »
Lymph system factors into cancer, diseases – Carthage Press
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Lymph system factors into cancer, diseases Carthage Press Lymph organs include the spleen, tonsils, adenoids, the thymus and the appendix. There also are lymph nodes – mostly in the neck, armpits and the groin – and specialized lymphatic tissue in the gastrointestinal tract. One major function of the lymph … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis […] περισσότερα »
Suppression of microphthalmia-associated transcription factor, but not NF-kappa B sensitizes melanoma specific cell death
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Mutation in B-Raf leads to gain of function in melanoma and causes aggressive behavior for proliferation. Most of the therapeutics are ineffective in this scenario. However, regulation of this aggressive behavior by targeting the key molecules would be viable strategy to develop novel and effective therapeutics. In this report we provide evidences that the […] περισσότερα »
A brave Sunderland dad has lost his battle with cancer – Sunderland Echo
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sunderland Echo A brave Sunderland dad has lost his battle with cancer Sunderland Echo A Sunderland dad who recorded messages for his family before his voicebox was removed has lost his battle with cancer. Ray Rodda, underwent the 13-hour operation to have his voicebox and tongue removed in 2014 after being diagnosed with throat … […] περισσότερα »
health technology; +213 new citations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
213 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2016/06/21 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content […] περισσότερα »
Laryngeal morphologic changes and epidemiology in patients with inhalation injury: a retrospective study.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laryngeal morphologic changes and epidemiology in patients with inhalation injury: a retrospective study.* Burns. 2015 Sep;41(6):1340-6 Authors: Fang-Gang N, Yang C, Yu-Xuan Q, Yan-Hua R, Wei-Li D, Cheng W, Chun-Quan W, Guo-An Z Abstract BACKGROUND AND OBJECTIVES: Laryngeal morphologic changes are important in risk assessment of upper airway obstruction (UAO) after inhalation injury. This retrospective study evaluates the clinical application of laryngeal burn classification system. MATERIALS AND METHODS: Clinica... περισσότερα »
Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.* Laryngoscope. 2016 Jun 19; Authors: Deep NL, Graffeo CS, Copeland WR, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML Abstract OBJECTIVES/HYPOTHESIS: To report two patients with a history of microvascular decompression (MVD) for hemifacial spasm who presented with Teflon granulomas (TG) mimicking cerebellopontine angle (CPA) tumors and to perform a systematic review of the English-language literature. STUDY DESIGN: Case series at a single tertiary academic referral center an... περισσότερα »
Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base.* Braz J Otorhinolaryngol. 2016 May 31; Authors: Dolci RL, Miyake MM, Tateno DA, Cançado NA, Campos CA, Dos Santos AR, Lazarini PR Abstract INTRODUCTION: The large increase in the number of transnasal endoscopic skull base surgeries is a consequence of greater knowledge of the anatomic region, the development of specific materials and instruments, and especially the use of the nasoseptal flap as a barrier between the sinus tract (contaminated cavity) and the subarachnoid sp... περισσότερα »
Intraoperative MRI in Skull Base Surgery: a review of 71 consecutive cases.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Intraoperative MRI in Skull Base Surgery: a review of 71 consecutive cases.* World Neurosurg. 2016 Jun 16; Authors: Ashour R, Reintjes S, Park MS, Sivakanthan S, van Loveren H, Agazzi S Abstract BACKGROUND: Although intraoperative magnetic resonance imaging (iMRI) is increasingly utilized during glioma resection, its role in skull base surgery has not been well documented. In this study, we evaluate our experience with iMRI for skull base surgery. METHODS: Medical records were retrospectively reviewed on all neurosurgical cases performed at our institution in the IMRIS® iMRI sui... περισσότερα »
Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Outcome Measurement in Adult Auditory Rehabilitation: A Scoping Review of Measures Used in Randomized Controlled Trials.* Ear Hear. 2015 Sep-Oct;36(5):567-73 Authors: Barker F, MacKenzie E, Elliott L, de Lusignan S Abstract OBJECTIVES: This review documented the range and nature of reported outcome measures in the context of adult auditory rehabilitative research. DESIGN: A scoping review conducted as a part of the development of a systematic review of the effect of interventions to improve hearing aid use. The au... περισσότερα »
Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects.* Acta Otolaryngol. 2016 Jun 20;:1-4 Authors: Wada Y, Nishiike S, Kitahara T, Yamanaka T, Imai T, Ito T, Sato G, Matsuda K, Kitamura Y, Takeda N Abstract CONCLUSION: After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags in trials 3-8, it is suggested that the adaptation to repeated visual-vestibulosomatosensory conflict in the VR world improved dynam... περισσότερα »
Preoperative Troponin in Patients Undergoing Noncardiac Surgery: Is Timing Everything?
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/28PhwT0 περισσότερα »
Timing of Preoperative Troponin Elevations and Postoperative Mortality After Noncardiac Surgery
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
[image: image]BACKGROUND: Even small elevations in preoperative troponin levels have been shown to be associated with adverse outcomes. However, there are currently limited data on the relationship between troponin increase and timing of surgery. METHODS: We performed a single-institution, retrospective cohort study of 6030 individuals with a troponin measurement made during the 30 days preceding a noncardiac surgical procedure. Subjects with detectable troponin levels were separated into terciles based on both the magnitude of the value and the time elapsed between this value and th... περισσότερα »
The Enigma of Postoperative Troponin Elevation
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/28Phr1H περισσότερα »
Rotigotine Transdermal Patch: A Review in Restless Legs Syndrome
Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες
Abstract Rotigotine transdermal patch (Leganto®, Neupro®) is indicated for the treatment of restless legs syndrome (RLS); this article reviews the pharmacological properties of rotigotine transdermal patch and its clinical efficacy and tolerability in patients with RLS. The transdermal patch allows for a continuous, stable release of rotigotine (avoiding first-pass metabolism), which in turn leads to continuous receptor stimulation, believed to closely mimic physiological striatal dopamine receptor function. In short-term and 6-month studies, especially at the higher dosages of 2 ... περισσότερα »
Primary Care Physicians' Adherence to Expert Recommendations for Cervical Cancer Screening and Prevention in the Context of Human Papillomavirus Vaccination.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Primary Care Physicians' Adherence to Expert Recommendations for Cervical Cancer Screening and Prevention in the Context of Human Papillomavirus Vaccination. Sex Transm Dis. 2016 Jul;43(7):438-444 Authors: Malo TL, Perkins RB, Lee JH, Vadaparampil ST Abstract BACKGROUND: Expert recommendations do not recommend using Papanicolaou (Pap) or human papillomavirus (HPV) test results to determine whether unvaccinated women […] περισσότερα »
Epidemiological evidence on environmental tobacco smoke and cancers other than lung or breast.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Epidemiological evidence on environmental tobacco smoke and cancers other than lung or breast. Regul Toxicol Pharmacol. 2016 Jun 16; Authors: Lee PN, Thornton AJ, Hamling JS Abstract We reviewed 87 epidemiological studies relating environmental tobacco smoke (ETS) exposure to risk of cancer other than lung or breast in never smoking adults. This updates a 2002 […] περισσότερα »
The Knowledge of the Role of Papillomavirus-Related Head and Neck Pathologies among General Practitioners, Otolaryngologists and Trainees. A Survey-Based Study.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Related Articles The Knowledge of the Role of Papillomavirus-Related Head and Neck Pathologies among General Practitioners, Otolaryngologists and Trainees. A Survey-Based Study. PLoS One. 2015;10(10):e0141003 Authors: Jackowska J, Bartochowska A, Karlik M, Wichtowski M, Tokarski M, Wierzbicka M Abstract OBJECTIVES: The aim of the survey was to introduce knowledge of HPV's role in head and […] περισσότερα »
Viral load and mRNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Related Articles Viral load and mRNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis. Laryngoscope. 2016 Jan;126(1):122-7 Authors: Forslund O, Schwartz S, Olofsson K, Rydell R Abstract OBJECTIVES/HYPOTHESIS: To determine viral load of human papillomavirus type 6 (HPV6), physical state of HPV6-DNA, and transcription level of HPV6 E7-mRNA in laryngeal papilloma and […] περισσότερα »
Surgery in head and neck cancer: United Kingdom National Multidisciplinary Guidelines - ERRATUM.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 2 ώρες
*Surgery in head and neck cancer: United Kingdom National Multidisciplinary Guidelines - ERRATUM.* J Laryngol Otol. 2016 Jun 20;:1 Authors: Homer JJ PMID: 27321287 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/28MG1kZ via IFTTT περισσότερα »
Using ultrasound tongue imaging to identify covert contrasts in children's speech.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 2 ώρες
*Using ultrasound tongue imaging to identify covert contrasts in children's speech.* Clin Linguist Phon. 2016 Jun 20;:1-14 Authors: Zharkova N, Gibbon FE, Lee A Abstract Ultrasound tongue imaging has become a promising technique for detecting covert contrasts, due to the developments in data analysis methods that allow for processing information on tongue shape from young children. An important feature concerning analyses of ultrasound data from children who are likely to produce covert contrasts is that the data are likely to be collected without head-to-transducer stabilisation... περισσότερα »
Prophylactic treatment of vestibular migraine.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 2 ώρες
*Prophylactic treatment of vestibular migraine.* Braz J Otorhinolaryngol. 2016 Jun 2; Authors: Salmito MC, Duarte JA, Morganti LO, Brandão PV, Nakao BH, Villa TR, Ganança FF Abstract INTRODUCTION: Vestibular migraine (VM) is now accepted as a common cause of episodic vertigo. Treatment of VM involves two situations: the vestibular symptom attacks and the period between attacks. For the latter, some prophylaxis methods can be used. The current recommendation is to use the same prophylactic drugs used for migraines, including β-blockers, antidepressants and anticonvulsants. The rec... περισσότερα »
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