PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.

Related Articles

PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.

HPB (Oxford). 2016 Jan;18(1):41-8

Authors: Lee SY, Kingham TP, LaGratta MD, Jessurun J, Cherqui D, Jarnagin WR, Kluger MD

Abstract
BACKGROUND: Hepatocellular adenoma (HCA) is the second most common benign liver neoplasm and occurs predominantly in women in their reproductive years. Positron emission tomography (PET) using [18F] fluorodeoxyglucose (FDG) is commonly used in cancer staging, surveillance and evaluation of treatment response. PET-avid HCA are rare and can be falsely interpreted as malignancies.
METHODS: A retrospective review of four institutions' database was performed to identify the PET-avid HCAs with clinico-pathological correlation.
RESULTS: Nine patients with histological proven PET-avid HCA was identified. Eight out of 9 patients were female with a median age at diagnosis of 44 years. All patients' tumors with available histological subtyping (8/8) were HNF1-α mutated and had no inflammatory changes; 6 out the 9 lesions had prominent (>50%) steatotic changes.
CONCLUSION: Hepatocellular adenomas, specifically the HNF1-α subtype, can cause false-positive PET findings when seeking to identify malignancy. Concomitantly, PET-CT may have the potential to identify the HCA histopathologic variant with the lowest malignant and hemorrhagic potential.

PMID: 26776850 [PubMed - indexed for MEDLINE]

http://ift.tt/2eKShTV