Genomic Insights in Gynecologic Cancer

Publication date: Available online 11 November 2016
Source:Current Problems in Cancer
Author(s): Erika Roddy, Jocelyn Chapman
Recent technological advances in DNA sequencing technology have enabled a remarkably detailed understanding of the molecular changes that define gynecologic and other cancers. Several groups have carried out large-scale genomic analyses of ovarian, uterine, and most recently, cervical cancer. These analyses have led to new insights into the molecular changes characterizing these cancers, which provides insight into clinical outcomes. These molecular characterizations have similarly led to new genomic-based classification schemas, which may better stratify clinical outcomes, help prognosticate and guide treatments. Discovery of characteristic mutations may also provide potential new targets for molecularly targeted chemotherapies, as has been already described with PARP inhibitors and ovarian cancer. The purpose of this review is to provide an overview of the defining molecular abnormalities and markers in gynecologic cancer, to discuss the clinical implications and to provide a comprehensive view of the current state of genomic knowledge in gynecologic cancer.



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