Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Τρίτη 15 Νοεμβρίου 2016

Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism.

Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism.

J Clin Endocrinol Metab. 2016 Nov 14;:jc20162728

Authors: Widdowson WM, McGowan A, Phelan J, Boran G, Reynolds J, Gibney J

Abstract
CONTEXT: Intestinal cholesterol metabolism is important in influencing post-prandial lipoprotein concentrations, and might be important in the development of vascular disease.
OBJECTIVE: This study evaluated associations between expression of intestinal cholesterol metabolism genes, postprandial lipid metabolism, and endothelial function/early vascular disease in human subjects. Design / Patients: One hundred patients undergoing routine oesophago-gastro-duedonscopy were recruited. mRNA levels of NPC1-L1, ABC-G5, ABC-G8, ABC-A1, MTTP, and SREBP-2 were measured in duodenal biopsies using rt-qPCR. Post-prandially, serum lipid and glycaemic profiles were measured, endothelial function was assessed using fasting and post-prandial FMD and carotid IMT was measured using B-mode ultrasonography. Subjects were divided into those above and below the median value of relative expression of each gene and results compared between the groups.
RESULTS: There were no between-group differences in demographic variables or classical cardiovascular risks. For all genes, the postprandial triglyceride incremental AUC was greater (P<0.05) in the group with greater expression. Post-prandial apoB48 levels were greater (P<0.05) in groups with greater expression of NPC1L1, ABC-G8, and SREBP-2. For all genes, post-prandial but not fasting FMD was greater (P<0.01) in the group with greater expression. Triglyceride and ApoB48 levels correlated significantly with postprandial FMD. CIMT was greater (P<0.05) in groups with greater expression of MTTP, ABC-A1, and SREBP-2.
CONCLUSION: Intestinal cholesterol metabolism gene expression is significantly associated with postprandial increment in TG, intestinal Apo B48, and reduced post-prandial FMD. Some genes were also associated with increased IMT. These findings suggest a role of intestinal cholesterol metabolism in development of early vascular disease.

PMID: 27841945 [PubMed - as supplied by publisher]



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