An ultrasensitive fluorescent probe for rapid determination of thiophenols

Publication date: 1 April 2017
Source:Talanta, Volume 165
Author(s): Lin Lin, Xiangqiong Zeng, Yuning Shen, Hailiang Zhu, Yong Qian
An ultrasensitive fluorescent probe TPP was developed for the highly selective detection of thiophenols based on excited-state intramolecular proton transfer (ESIPT) mechanism, its synthesis through a simple straightforward combination of HBT fluorophore with 2,4-dinitrobenzene functional group. A kinetic study of TPP towards thiophenol displayed a fast response time (~150s) and significant turn-on fluorescence enhancement (~60 fold). Selective and competitive experiments exhibited an excellent selectivity of TPP toward thiophenols over biothiols (Cys, GSH) and other aliphatic thiols or nucleophiles. Using this ultrasensitive probe (LOD, 1.05×10⁻⁸M), we have successfully monitored and quantified highly toxic thiophenols in aqueous media and real-water samples.

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