Development of a Global Respiratory Severity Score (GRSS) for Respiratory Syncytial Virus Infection in Infants.

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Development of a Global Respiratory Severity Score (GRSS) for Respiratory Syncytial Virus Infection in Infants.

J Infect Dis. 2016 Dec 23;:

Authors: Caserta MT, Qiu X, Tesini B, Wang L, Murphy A, Corbett A, Falsey AR, Holden-Wiltse J, Walsh EE

Abstract
BACKGROUND: RSV infection in infants has recognizable clinical signs and symptoms. However, quantification of disease severity is difficult and published scores remain problematic. Thus, as part of a RSV pathogenesis study we developed a Global Respiratory Severity Score (GRSS) in infants with primary RSV infection as a research tool.
METHODS: Previously healthy infants under 10 months of age representing the spectrum of RSV severity were prospectively evaluated. Clinical signs and symptoms were collected at three time points in hospitalized infants and those seen in ambulatory settings. Data were also extracted from office, emergency department and hospital records. An unbiased data driven approach using factor analysis was performed to develop a GRSS.
RESULTS: 139 infants were enrolled (84 hospitalized, 55 non-hospitalized). Using hospitalization status as the output variable, nine clinical variables were identified and weighted to produce a composite GRSS. The GRSS had an area under the receiver operator curve of 0.961. Construct validity was demonstrated via a significant correlation with length of stay (r = .586, p<.0001).
CONCLUSIONS: Using routine clinical variables we developed a severity score for infants with RSV infection that should be useful as an endpoint for investigation of disease pathogenesis, and an outcome of therapeutic intervention.

PMID: 28011907 [PubMed - as supplied by publisher]

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