Prognostic Differences: Epstein-Barr Virus Associated Primary Leiomyosarcoma of the Spine versus Spinal Leiomyosarcoma Metastases.

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Prognostic Differences: Epstein-Barr Virus Associated Primary Leiomyosarcoma of the Spine versus Spinal Leiomyosarcoma Metastases.

World Neurosurg. 2016 Dec 21;:

Authors: Agarwal N, Hansberry DR, Kavi A, Agarwal P, Baisre A, Goldstein IM

Abstract
The authors present six cases of osseous leiomyosarcoma of the spine. Two of these cases are of immunocompromised human immunodeficiency virus (HIV) positive patients with Epstein-Barr virus (EBV) associated primary vertebral leiomyosarcomas. The remaining four cases are of patients with leiomyosarcoma metastases to the spine. Each patient underwent surgical resection of their vertebral mass; however, the patients with the EBV associated tumors had the best postoperative prognosis. The HIV-positive patients have had no further local recurrence, while the other four patients had rapid local recurrences requiring multiple surgical interventions. Furthermore, the patients living with HIV have lived longer with fewer leiomyosarcoma related health complications. This finding suggests that the EBV associated vertebral leiomyosarcoma is of a less aggressive variety than metastatic leiomyosarcoma of the spine.

PMID: 28011357 [PubMed - as supplied by publisher]

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