In silico analysis of toxins of Staphylococcus aureus for validating putative drug targets.

In silico analysis of toxins of Staphylococcus aureus for validating putative drug targets.

Infect Disord Drug Targets. 2016 Dec 30;

Authors: Mohana R, Venugopal S

Abstract
Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that causes detrimental effects of human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation. The results inferred that the toxins were found to interact with many protein partners and found no homologous sequences for human proteome and based on similarity search in Drugbank the targets were identified as novel drug target.

PMID: 28034364 [PubMed - as supplied by publisher]

http://ift.tt/2iQ5qzm