Quinolines: Microwave-assisted Synthesis and their Antifungal, Anticancer and Radical Scavenger Properties

Publication date: Available online 21 December 2016
Source:Bioorganic & Medicinal Chemistry
Author(s): Natália Aparecida Liberto, Juliana Baptista Simões, Sarah de Paiva Silva, Cristiane Jovelina da Silva, Luzia Valentina Modolo, Ângelo de Fátima, Luciana Maria Silva, Marcos Derita, Susana Zacchino, Omar Miguel Portilla Zuñiga, Gustavo Pablo Romanelli, Sergio Antonio Fernandes
An efficient method for the synthesis of quinolines using microwave irradiation was developed providing 28 quinolines with good yields. The reaction procedures are environmentally friendly, convenient, mild and of easy work-up. Quinolines were evaluated for their antifungal, anticancer and antioxidant properties and exhibited high activities in all tests performed.

Graphical abstract

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