Radiosurgery for liver metastases. A single institution experience

Publication date: Available online 21 December 2016
Source:Reports of Practical Oncology & Radiotherapy
Author(s): Beatriz Amendola, Marco Amendola, Jesús M. Blanco, Naipy Perez, Xiaodong Wu
AimTo report our initial results on the use of radiosurgery for treatment of liver metastases.BackgroundIn recent years there has been increasing interest in the use of stereotactic body radiation therapy to treat metastatic disease to the liver as an alternative to interventional procedures.Materials and methodsBetween November 2008 and June 2015 a total of 36 LINAC-based radiosurgeries using VMAT were performed in 27 patients with liver metastases from 10 different primary sites. Doses ranged from 21Gy to 60Gy in 1 to 5 fractions. In all patients the volume of liver receiving less than 15Gy was more than 700cc. The volume treated with the prescription dose ranged from 1cc to 407cc with a median of 58cc. All patients but one received systemic treatment.ResultsOverall median survival for the entire group is 9 months (ranging from 1 to 67 months). Local recurrence free survival ranged from 4 to 67 months with a median of 14 months.Twenty patients (80%) survived more than six months. Three patients treated for oligometastases were alive after 3 years. Grade 0 toxicity was encountered in 22/27 patients, Grade 1 toxicity in 5/27 and only 1/27 patient experienced Grade 2 toxicity. No patient experienced grade 3–4 toxicity.ConclusionBased on these initial results we conclude that SBRT for treating liver metastases with radiosurgery is safe and effective for treating one or multiple lesions as long as normal tissue constraints for liver are respected.



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