Publication date: March 2017
Source:Biomaterials, Volume 121
Author(s): Zi-Fei Zhou, Tuan-Wei Sun, Feng Chen, Dong-Qing Zuo, Hong-Sheng Wang, Ying-Qi Hua, Zheng-Dong Cai, Jun Tan
Biocompatibility, biodegradability and bioactivity are significantly important in practical applications of various biomaterials for bone tissue engineering. Herein, we develop a functional inorganic-organic hybrid system of calcium phosphate-phosphorylated adenosine (CPPA). Both calcium phosphate and phosphorylated adenosine molecules in CPPA are fundamental components in mammalians and play important roles in biological metabolism. In this work, we report our three leading research qualities: (1) CPPA hybrid microspheres with hollow and porous structure are synthesized by a facile one-step microwave-assisted solvothermal method; (2) CPPA hybrid microspheres show high doxorubicin loading capacity and pH-responsive drug release properties, and demonstrate positive therapeutic effects on six osteosarcoma cell lines in vitro and a mouse model of 143B osteosarcoma subcutaneous tumor in vivo; (3) CPPA hybrid microspheres are favorable to promote osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) by activating the AMPK pathway, with satisfactory evidences from cellular alkaline phosphatase staining, alizarin red staining, real time PCR and western analysis. The as-prepared CPPA hybrid microspheres are promising in anti-osteosarcoma and bone regeneration, which simultaneously display excellent properties on drug delivery and osteogenic differentiation of hBMSCs.
http://ift.tt/2iGxYuo
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- Targeting Epidermal Growth Factor Receptor in Trip...
- Conservative surgery for laryngeal chondrosarcoma:...
- Airway Management With a Stereotactic Headframe In...
- Hemodynamic monitoring in thoracic surgical patients.
- Efferent Vision Therapy.
- Neuro-Ophthalmology in Portugal.
- A Giant Tumefactive Virshow-Robin Space: A Rare Ca...
- Colon Metastasis to Residual Pituitary Macroadenom...
- Acknowledgements to reviewers
- Upper aerodigestive tract cancer: summary of the N...
- A stratified analysis of the perioperative outcome...
- Protective benefit of predominant breastfeeding ag...
- The clinical diagnostic value of target biopsy usi...
- An Asian perspective on improving outcomes for nas...
- Evaluation of nasal patency by visual analogue sca...
- Acknowledgements to reviewers
- A systematic review of the surgical techniques for...
- Upper aerodigestive tract cancer: summary of the N...
- Structured training on the da Vinci Skills Simulat...
- A stratified analysis of the perioperative outcome...
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