Publication date: April 2017
Source:Biomedicine & Pharmacotherapy, Volume 88
Author(s): XinGang Lu, Li Min, JiongLin Wei, HaiXin Gou, ZhiJun Bao, JiaoFeng Wang, Zheng Wang, YiZhi Huang, BingChen An
The heliangin is a natural agent mainly isolated from Helianthus tuberosus L. (Asteraceae). In order to investigate the anti-inflammatory effect of heliangin, several typical models in vivo and in vitro were performed. The RAW264.7 mouse macrophages cells were employed in vitro and dexamethasone were conducted as positive. The cytotoxicity results of heliangin on RAW 264.7 cells provided the safety in vitro for further study. The mRNA of TNF-α, IL-6, iNOS and COX-2 were degraded under heliangin exposure in LPS-stimulated RAW 264.7 cells. The protein expression of iNOS, COX-2 were decreased via heliangin exposure in a dose-dependent manner. Heliangin inhibited TNF-α, NO, IL-6 and PGE2 expression levels in macrophage cells lysate. The immunocytochemistry assay showed the fluorescence image of heliangin treatment intercepted the p65 translocation process from outside to inside of nuclei triggered by LPS. Moreover, we founded that MAPK and NF-κB signaling pathway play important roles in heliangin's activity on RAW264.7 cells. Secondly, the acute toxic study results of heliangin manifested the safety in vivo. Heliangin exerted anti-inflammation effect in a xylene-induced ear swelling in BALB/C mice and carrageenan-induced paw edema model in SD rats. The cytokines levels (TNF-α, IL-6 and PGE2) were decreased. The paw tissue immunochemistry assay demonstrated the IL-6 protein level changes in carrageenan-induced paw edema model under heliangin administration.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Η λίστα ιστολογίων μου
Κυριακή 15 Ιανουαρίου 2017
Heliangin inhibited lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells
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- The efficiency of Eichhornia crassipes in the remo...
- Oropharyngeal swabs analyzed by ddPCR is a quantit...
- Tumor uptake of 18F-BPA and 11C-Met : The distribu...
- Establishment of critical limits of indicators and...
- Antimicrobial photodynamic therapy as an adjunct f...
- Update on Auditory Evoked Responses: Evidence-Base...
- Book Review—Hematopathology, 2nd edition
- The association between sclerostin and incident ty...
- Can't intubate can't ventilate, use a small size A...
- Acute renal injury in the course of a large pleura...
- The sedative effects of the intranasal administrat...
- Immune transcriptome reveals the mincle C-type lec...
- Immune transcriptome reveals the mincle C-type lec...
- Linking organic anion transporting polypeptide 1B1...
- Sitagliptin inhibit human lymphocytes proliferatio...
- A calix[4]arene derivative and its selective inter...
- Immune regulatory network in successful pregnancy ...
- A systems pharmacology perspective to decipher the...
- Establishment of a fluorescence-based method to ev...
- Heliangin inhibited lipopolysaccharide-induced inf...
- American Thyroid Association Guidelines for Diagno...
- American Thyroid Association Guidelines for Diagno...
- The stability of gadolinium-based contrast agents ...
- Assessment of gait and sensorimotor deficits in th...
- Autophagy and autoimmunity
- Autophagy and autoimmunity
- Ultrasensitive detection of oncogenic human papill...
- Ultrasensitive detection of oncogenic human papill...
- Use of an intraoperative navigation system for ret...
- The implantable loop recorder and its mammographic...
- Emergency color Doppler sonography of the extremit...
- Use of an intraoperative navigation system for ret...
- Anti-angiogenic treatment in breast cancer: Facts,...
- Strategies to design clinical studies to identify ...
- Diverse role of Survival Motor Neuron Protein
- TDP-43 pathology and memory impairment in elders w...
- Neuropathology of SUDEP: Role of inflammation, blo...
- Spontaneous ischaemic stroke lesions in a dog brai...
- Care pathway of patients with metastatic pancreati...
- [La Société Française du Cancer is moving forward].
- Cochlear synaptopathy in acquired sensorineural he...
- Mitochondrial reactive oxygen species regulate fun...
- Regulatory T cells and IL10 suppress pulmonary hos...
- Aspirin prevents TNF-α-induced endothelial cell dy...
- miR-24 Inhibition Increases Menin Expression and D...
- Delta-like 4/Notch signaling promotes Apc (Min/+) ...
- Anti-angiogenic treatment in breast cancer: Facts,...
- Strategies to design clinical studies to identify ...
- Overview of the benefits and potential issues of t...
- Prognostic and predictive indicators in early-stag...
- In vitro eye irritation testing using the open sou...
- Severe hypoalbuminemia and steatohepatitis leading...
- Underuse of screening in Osler-Weber-Rendu syndrome.
- Reply to letter regarding submission entitled: Cra...
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- Retraction note: Triptolide contributes to decreas...
- Morel-Lavallée Injuries: A Multimodality Approach ...
- Immunohistochemical study of Metallothionein in pa...
- Spontaneous peritoneal catheter knot formation: A ...
- Alterations of brain activity in fibromyalgia pati...
- Report of a familial case of proatlas segmentation...
- Assessment of GAPDH expression by quantitative rea...
- Operative fusion of multilevel cervical spondyloti...
- Gender ratio trends over time in multiple sclerosi...
- Spontaneous subdural haemorrhage due to meningioma...
- The filum terminale internum and externum: A compr...
- Clinical characteristics of ruptured distal middle...
- Co-expression of tissue factor and IL-6 in immatur...
- Evaluation of artifacts generated by zirconium imp...
- Enamel-renal syndrome in 2 patients with a mutatio...
- Postmyelotomy closure of spinal cord - "Zip lock t...
- Exploration of the Most Effective Dural Incision D...
- Bone grafting of atlantoaxial joints and occipitoc...
- Stenting after coiling using a single microcathete...
- Characteristics of Moderate and Severe Traumatic B...
- Ryanodine receptor 1 polymorphism is not associate...
- Preadolescent sensation seeking and early adolesce...
- Hypopharyngeal cancer masquerading as a thyroid mass.
- [Effect of methyleugenol on expression of MUC5AC i...
- Culture media-based selection of endothelial cells...
- The path of a click stimulus from ear canal to umbo.
- Audiologic and radiologic findings in cochlear hyp...
- Radioiodine sinus uptake related to mucosal thicke...
- A comparative analysis between sequential boost an...
- Improved cognition while cycling in Parkinson's di...
- Laparoscopic versus open surgery for rectal cancer...
- Anatomical and Clinical Study of the Posterior Aur...
- Disparities in Utilization of Jaw Surgery for Trea...
- Platysma Motor Nerve Transfer for Restoring Margin...
- Abstract: Why Women Request Labiaplasty
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