Publication date: March 2017
Source:Molecular Immunology, Volume 83
Author(s): Emmanuelle Zoccola, Stuart Kellie, Andrew C. Barnes
Fish represent the most diverse and abundant extant vertebrate infraclass. They are also one of the earliest divergent phyla with adaptive immunity based on antigen recognition by MHC and immunoglobulin. The aquaculture industry, which currently provides more than half of the fish for human consumption globally, has successfully exploited the adaptive immune system of fish through mass vaccination programs. However, vaccination against highly diverse antigens, mostly carbohydrates, such as capsular polysaccharides and lipopolysaccharide (LPS) is challenging. Fish have a subdued innate response to LPS, but adaptive response is generally high and type-specific. To better understand the link between initial innate response and early onset of adaptive immunity to carbohydrate antigens in the perciform barramundi (Lates calcarifer), an immune transcriptome was prepared from pronephros and spleen following vaccination with LPS and peptidoglycan. From 163,661 transcripts derived by Illumina mRNA-Seq, most grouped in neuronal, endocrine or immune system categories, suggesting a close relationship between the three systems. Moreover, digestive enzyme transcripts in spleen appeared to be highly inducible in barramundi. Most of the known TLRs were transcribed in the barramundi spleen and HK transcriptome, with the notable exception of TLR4, which is primarily responsible for LPS recognition in mammals. Several C-type lectin receptors were also identified, including CD209, CD205, and CLEC4E (Mincle). As Mincle has been shown to bind LPS and is abundant on dendritic cells, its role in response to LPS in barramundi was further investigated. A high dose of LPS induced TNF-alpha expression via Mincle. However, IL-6 regulation, whilst still regulated in response to LPS, did not depend upon the Mincle pathway, suggesting other routes of activation. This study thus suggests that Mincle acts as a partial substitute for TLR4 in barramundi in the processing of LPS.
http://ift.tt/2jlOctv
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ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
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00302841026182
00306932607174
alsfakia@gmail.com
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- Oropharyngeal swabs analyzed by ddPCR is a quantit...
- Tumor uptake of 18F-BPA and 11C-Met : The distribu...
- Establishment of critical limits of indicators and...
- Antimicrobial photodynamic therapy as an adjunct f...
- Update on Auditory Evoked Responses: Evidence-Base...
- Book Review—Hematopathology, 2nd edition
- The association between sclerostin and incident ty...
- Can't intubate can't ventilate, use a small size A...
- Acute renal injury in the course of a large pleura...
- The sedative effects of the intranasal administrat...
- Immune transcriptome reveals the mincle C-type lec...
- Immune transcriptome reveals the mincle C-type lec...
- Linking organic anion transporting polypeptide 1B1...
- Sitagliptin inhibit human lymphocytes proliferatio...
- A calix[4]arene derivative and its selective inter...
- Immune regulatory network in successful pregnancy ...
- A systems pharmacology perspective to decipher the...
- Establishment of a fluorescence-based method to ev...
- Heliangin inhibited lipopolysaccharide-induced inf...
- American Thyroid Association Guidelines for Diagno...
- American Thyroid Association Guidelines for Diagno...
- The stability of gadolinium-based contrast agents ...
- Assessment of gait and sensorimotor deficits in th...
- Autophagy and autoimmunity
- Autophagy and autoimmunity
- Ultrasensitive detection of oncogenic human papill...
- Ultrasensitive detection of oncogenic human papill...
- Use of an intraoperative navigation system for ret...
- The implantable loop recorder and its mammographic...
- Emergency color Doppler sonography of the extremit...
- Use of an intraoperative navigation system for ret...
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- Strategies to design clinical studies to identify ...
- Diverse role of Survival Motor Neuron Protein
- TDP-43 pathology and memory impairment in elders w...
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- Spontaneous ischaemic stroke lesions in a dog brai...
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- [La Société Française du Cancer is moving forward].
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- Regulatory T cells and IL10 suppress pulmonary hos...
- Aspirin prevents TNF-α-induced endothelial cell dy...
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- Strategies to design clinical studies to identify ...
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- Co-expression of tissue factor and IL-6 in immatur...
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- [Effect of methyleugenol on expression of MUC5AC i...
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- The path of a click stimulus from ear canal to umbo.
- Audiologic and radiologic findings in cochlear hyp...
- Radioiodine sinus uptake related to mucosal thicke...
- A comparative analysis between sequential boost an...
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