Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin's lymphoma.

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Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin's lymphoma.

BMJ Case Rep. 2016 Apr 26;2016:

Authors: Elderman JH, Wabbijn M, de Jongh F

Abstract
Oncogenic osteomalacia (or tumour-induced osteomalacia) is a rare paraneoplastic syndrome caused by overproduction of fibroblastic growth factor 23 (FGF-23) by tumours. Excessive production of FGF-23 can lead to severe, symptomatic hypophosphataemia. The majority of cases have been associated with benign tumours of bone or soft tissue, such as haemangiopericytomas or other neoplasms of mesenchymal origin. We present a case of a 68-year-old woman with an FGF-23 producing B cell non-Hodgkin's lymphoma. Treatment with immunochemotherapy resulted in normalisation of serum FGF-23 and phosphate levels.

PMID: 27118742 [PubMed - indexed for MEDLINE]

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