Is von Willebrand Disease linked to cholesteatoma aetiology?

Publication date: Available online 23 January 2017
Source:Medical Hypotheses
Author(s): Â. Reis Rego, M. Santos, M. Coutinho, T. Feliciano, C. Almeida e Sousa
Cholesteatoma is a common clinical picture seen by the otolaryngologists. The disease is characterised by an abnormal grow "of skin in the wrong place". Specifically, in acquired cholesteatoma, the main causative issue is associated with ventilatory deficits within the middle ear and results in chronic infection. Molecular science has associated the presence of specific molecules with its development, and moreoverrecent research suggests that deregulated angiogenesis is a crucial process in the development of cholesteatoma and its recurrence. Further, haematologists have linked von Willebrand factor and its defects (both quantitative and qualitative) to augmented angiogenesis through upregulation of the vascular endothelial growth factor and angiogenic cytokines. Thus, herewith we probed whether a relationship between von Willebrand disease and the etiopathogenesis of cholesteatoma, plays a potential role for anti-angiogenic molecules for the advent of cholesteatoma surgery adjuvant treatment.



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