Abstract
Objectives
Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement and management outcomes were performed.
Subjects and Methods
Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included.
Results
There were 26 MMP (46%) and 31 PV (54%) patients. Desquamative gingivitis was evident in 84% of MMP cases compared to 26% of PV cases (p<0.05). Non-gingival lesions were noted in 6% of MMP cases compared to 55% of PV cases (p<0.01). Management of MMP consisted of only topical corticosteroids in 88% of cases while 12% of cases required concomitant systemic therapy. All PV cases (100%) required systemic therapy. No patients with MMP developed scarring or ocular lesions, and one patient (4%) developed cutaneous lesions. Five PV cases (16%) had oral cavity involvement only with 3 (60%) developing pharyngeal involvement and 2 (40%) developing cutaneous lesions on follow-up.
Conclusion
Oral MMP presents primarily as desquamative gingivitis, infrequently involving extra-gingival sites, and is highly amenable to topical therapy, while PV is a systemic mucocutaneous disease with extensive non-gingival oral lesions that almost always requires systemic therapy.
This article is protected by copyright. All rights reserved.
http://ift.tt/2j77kJi
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου