Possible inducible skin-associated lymphoid tissues (iSALT)-like structures with CXCL13+ fibroblast-like cells in secondary syphilis

Abstract

Non-lymphoid organs, are not merely the sites for effector T-cell-function.Ectopic accumulations of lymphoid cells arise in non-lymphoid organs under long-lived self-perpetuating chronic inflammation.¹ These accumulations are called tertiary lymphoid organs (TLOs), and they function as antigen-presenting sites.¹ TLOs are characterized by their cellular, organizational, chemokine, and vascular similarity to lymph nodes (LNs).¹

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