Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors

Publication date: Available online 30 January 2017
Source:Microbes and Infection
Author(s): Emily C. Woods, Shonna M. McBride
Extracytoplasmic function (ECF) sigma factors are a subfamily of σ⁷⁰ sigma factors that activate genes involved in stress-response functions. In many bacteria, ECF sigma factors regulate resistance to antimicrobial compounds. This review will summarize the ECF sigma factors that regulate antimicrobial resistance in model organisms and clinically relevant pathogens.



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