Squamous cell carcinoma with enteric adenocarcinomatous differentiation

Abstract

We report a highly unusual case of a primary cutaneous squamous cell carcinoma with intermixed enteric-type adenocarcinomatous dedifferentiation and a small component of undifferentiated mesenchymal differentiation. We believe this is the first time this form of phenotypic plasticity has been described in cutaneous squamous cell carcinoma.

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