A Case of Eosinophilic Fasciitis Associated with Pyoderma Gangrenosum

Abstract

Eosinophilic fasciitis (EF) is a rare, systemic inflammatory disease that is characterized by symmetrical swelling and scleroderma-like indurations of the distal extremities and trunk, often accompanied by pain and eosinophilia. Rarely, muscle degeneration may occur. Histologically, EF is marked by thickened, fibrotic fascia and fascial inflammation with lymphocytes and eosinophils.^1,2 Herein, we present a previously unreported case of concurrent pyoderma gangrenosum (PG) and biopsy-proven EF successfully treated with rituximab.

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