ELMO3 predicts poor outcome in T1 laryngeal cancer

Abstract

Objectives

Despite the excellent overall survival of 92-97% in early glottic cancer, recurrence rates of 13-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) has been described as prognostic marker in lung cancer patients. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome.

Design, setting and participant

48 patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analyzed. ELMO3 expression of the tumor was assessed using immunohistochemistry and correlated to clinical data.

Main outcome measure

Overall survival (OS), disease specific survival (DSS) and disease-free survival (DFS) rates

Results

Positive ELMO3 expression was found in 23% of the patients and was correlated to poor DSS and DFS (p < 0.05).

Conclusion

This is the first study to show a prognostic effect of positive ELMO3 expression in early glottic carcinoma patients.

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