Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity

Publication date: Available online 12 February 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Ammar Maryamabadi, Alireza Hasaninejad, Najmeh Nowrouzi, Gholamhossein Mohebbi
A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N'-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in-vitro and in-silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.

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