Publication date: Available online 1 February 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Waise Quarni, Panida Lungchukiet, Anfernee Tse, Pei Wang, Yuefeng Sun, Ravi Kasiappan, Jheng-Yu Wu, Xiaohong Zhang, Wenlong Bai
Receptor interacting protein kinase 1 (RIPK1) is an enzyme acting downstream of tumor necrosis factor alpha to control cell survival and death. RIPK1 expression has been reported to cause drug resistance in cancer cells, but so far, no published studies have investigated the role of RIPK1 in vitamin D signaling. In the present study, we investigated whether RIPK1 plays any roles in 1,25-dihydroxyvitamin D3 (1,25D3)-induced growth suppression. In our studies, RIPK1 decreased the transcriptional activity of vitamin D receptor (VDR) in luciferase reporter assays independent of its kinase activity, suggesting a negative role of RIPK1 in 1,25D3 action. RIPK1 also formed a complex with VDR, and deletion analyses mapped the RIPK1 binding region to the C-terminal ligand-binding domain of the VDR. Subcellular fractionation analyses indicated that RIPK1 increased VDR retention in the cytoplasm, which may account for its inhibition of VDR transcriptional activity. Consistent with the reporter analyses, 1,25D3-induced growth suppression was more pronounced in RIPK1-null MEFs and RIPK1-knockdown ovarian cancer cells than in control cells. Our studies have defined RIPK1 as a VDR repressor, projecting RIPK1 depletion as a potential strategy to increase the potency of 1,25D3 and its analogs for cancer intervention.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Τετάρτη 1 Φεβρουαρίου 2017
RIPK1 binds to vitamin D receptor and decreases vitamin D-induced growth suppression
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- Study of efficacy of esthetic High-Intensity Focus...
- The efficacy study of the combination of tripeptid...
- Chemotherapy-induced alopecia management: Clinical...
- Characterizing the detectability of emission signa...
- Public member dose assessment of Bushehr Nuclear P...
- Radioactivity levels in the mostly local foodstuff...
- Duplication Anomalies of the Internal Auditory Can...
- Duplication Anomalies of the Internal Auditory Can...
- Coercive Control, Physical Violence, and Masculinity
- Treatment pattern and frequency of serum TSH measu...
- Primary Thyroid Carcinoma with Low-Risk Histology ...
- Effects of Adequate Iodine Supply on the Incidence...
- Acknowledgment of Reviewers
- Shigenobu Nagataki (January 18, 1932–November 12, ...
- Future Meetings
- Primary Thyroid Carcinoma with Low-Risk Histology ...
- Effects of Adequate Iodine Supply on the Incidence...
- Acknowledgment of Reviewers
- Shigenobu Nagataki (January 18, 1932–November 12, ...
- Future Meetings
- Blockage of androgen and administration of estroge...
- Quantifying 125I placement accuracy in prostate br...
- MRI in prostate brachytherapy: Evidence, clinical ...
- Dosimetric and radiobiologic comparison of 103Pd C...
- Deformable image registration for cervical cancer ...
- Brachytherapy boost for prostate cancer: Trends in...
- New application of three-dimensional printing biom...
- Adjuvant radiotherapy is not supported in patients...
- Target volume and artifact evaluation of a new dat...
- Improving patient safety and workflow efficiency w...
- New application of three-dimensional printing biom...
- Adjuvant radiotherapy is not supported in patients...
- [Current position of new fixed-dose combination of...
- Validation of a new snoring detection device based...
- Facial nerve paralysis associated with temporal bo...
- MEG and EEG demonstrate similar test-retest reliab...
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- Diagnostic Agreement and Interobserver Concordance...
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- Size control of aromatic polyamide hollow spheres ...
- Modeling the formation of layered, amphiphilic gels
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- An abnormal melting behavior of isotactic polyprop...
- Investigation of the biocompatibility and cytotoxi...
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- Rheological behavior of polyacrylonitrile and poly...
- Dynamic, ultra-pH-sensitive graft copolymer micell...
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- Letter from the Guest Editor: Pelvic MR Imaging
- Speech-Language Pathologists' Use of Hearing Scree...
- Methylphenidate effects on P300 responses from chi...
- Fully-covered metallic stenting in an infant with ...
- Upper Eyelid Reconstruction Using a Blepharoplasty...
- Effect of nebulized budesonide on decreasing the r...
- Effect of nebulized budesonide on decreasing the r...
- Is Surgical Navigation Useful During Closed Reduct...
- Relations of Facial Nerve With Retromandibular Vei...
- Characteristics of Pediatric Cheek Mass.
- Anatomical Study of the Infraorbital Nerve and Sur...
- Reconstruction of Extensive Orbital Exenteration D...
- Open Reduction in Pediatric Condylar Fracture.
- Is Presence of Vascular Loop in Magnetic Resonance...
- Combined Endoscopic and Trans Palpebral Orbital Re...
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- Endoscopic Endonasal Transsphenoidal Approach From...
- A Surgical Technique for Management of the Metopic...
- Survey of Ocular Prosthetics Rehabilitation in the...
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- The Rapid Development of Squamous Cell Carcinoma o...
- Inappropriate Management After Accidental Displace...
- A Rare Case of Malignant Fibrous Histiocytoma (Und...
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- Methotrexate Induces Apoptosis in Organ-Cultured N...
- The Making of a Skull Base Team and the Value of M...
- Using the Endoscopic Transconjunctival and Transca...
- Overview of Sinonasal and Ventral Skull Base Malig...
- The Role of Chemotherapy in the Management of Sino...
- Survival, Morbidity, and Quality-of-Life Outcomes ...
- Editorial Board
- Overview of Sinonasal and Ventral Skull Base Malig...
- The Making of a Skull Base Team and the Value of M...
- The Role of Chemotherapy in the Management of Sino...
- Survival, Morbidity, and Quality-of-Life Outcomes ...
- Validation of a new snoring detection device based...
- Facial nerve paralysis associated with temporal bo...
- Tell me how pleased you are with your workplace, a...
- The suppressive effects of landiolol administratio...
- Validation of a new snoring detection device based...
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