TNF α (-308G>A) And TNF-R1 (36A>G) Single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development

Abstract

Background

Polymorphisms in genes encoding tumor necrosis factor α (TNF α) and its receptor TNF-R1, have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF α (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients.

Methods

Genotyping was done in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis.

Results

A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P<0.05). Carriers of the TNF α A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P<0.0001), whilst carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR=3.65, CI 1.60-8.40, P=0.001).

Conclusions

Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.

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