WNK Kinase Signaling in Ion Homeostasis and Human Disease

Publication date: 7 February 2017
Source:Cell Metabolism, Volume 25, Issue 2
Author(s): Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David H. Ellison, Eric Delpire, Kristopher T. Kahle
WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl⁻ cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Teaser

WNK kinases are essential regulators of ion homeostasis in a wide array of human tissues. Shekarabi et al. review the roles of WNK kinases in diverse physiologic and pathophysiologic states. Study of WNK kinases promises to yield novel mechanistic insights and new therapeutic targets for several human diseases.


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