Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Raimo A. Salo, Tuukka Miettinen, Teemu Laitinen, Olli Gröhn, Alejandra Sierra
Imaging markers for monitoring disease progression, recovery, and treatment efficacy are a major unmet need for many neurological diseases, including epilepsy. Recent evidence suggests that diffusion tensor imaging (DTI) provides high microstructural contrast even outside major white matter tracts. We hypothesized that in vivo DTI could detect progressive microstructural changes in the dentate gyrus and the hippocampal CA3bc in the rat brain after status epilepticus (SE). To test this hypothesis, we induced SE with systemic kainic acid or pilocarpine in adult male Wistar rats and subsequently scanned them using in vivo DTI at five time-points: prior to SE, and 10, 20, 34, and 79 days post SE. In order to tie the DTI findings to changes in the tissue microstructure, myelin- and glial fibrillary acidic protein (GFAP)-stained sections from the same animals underwent Fourier analysis. We compared the Fourier analysis parameters, anisotropy index and angle of myelinated axons or astrocyte processes, to corresponding DTI parameters, fractional anisotropy (FA) and the orientation angle of the principal eigenvector. We found progressive detectable changes in DTI parameters in both the dentate gyrus (FA, axial diffusivity [D||], linear anisotropy [CL] and spherical anisotropy [CS], p<0.001, linear mixed-effects model [LMEM]) and the CA3bc (FA, D||, CS, and angle, p<0.001, LMEM; CL and planar anisotropy [CP], p<0.01, LMEM) post SE. The Fourier analysis revealed that both myelinated axons and astrocyte processes played a role in the water diffusion anisotropy changes detected by DTI in individual portions of the dentate gyrus (suprapyramidal blade, mid-portion, and infrapyramidal blade). In the whole dentate gyrus, myelinated axons markedly contributed to the water diffusion changes. In CA3bc as well as in CA3b and CA3c, both myelinated axons and astrocyte processes contributed to water diffusion anisotropy and orientation. Our study revealed that DTI is a promising method for noninvasive detection of microstructural alterations in the hippocampus proper. These alterations may be potential imaging markers for epileptogenesis.
http://ift.tt/2noLstL
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Μαρτίου
(11966)
-
▼
Μαρ 10
(677)
- Application of Ultrasound-guided Pigtail Catheter ...
- City Noise Positively Correlates with Hearing Loss
- Application of Ultrasound-guided Pigtail Catheter ...
- Issue Information - Contents
- Cover Image
- Issue Information - Contents
- Cover Image
- Construct validity—Current issues and recommendati...
- Universal versus targeted additional contact preca...
- Gestational diabetes mellitus: an updated overview
- Contrast reaction training in US radiology residen...
- Response to Tulchinsky and Avram re: “Long-Term Ou...
- Response to Tulchinsky and Avram re: “Long-Term Ou...
- Vaccine Development
- Cell membrane integrity and revascularization: The...
- Skill-related physical fitness versus aerobic fitn...
- Radical Dissection of Greater Palatine Artery and ...
- Unilateral Pterional Polycraniosynostosis Treated ...
- Usefulness of self-report questionnaires for psych...
- Dynamics of progesterone and estrogen receptor alp...
- Confined polymerization: ARGET ATRP of MMA in the ...
- Effect of compositions of acceptor polymers on dar...
- Synergistic dielectric and semiconducting properti...
- Organogelation of self-assembling segmented poly(u...
- Effect of transfer agent, temperature and initial ...
- Corrigendum to “Is meditation always relaxing? Inv...
- The relationship of approach/avoidance motivation ...
- The Incidence and Health Care Resource Burden of t...
- Clinical Benefit in Response to Palbociclib Treatm...
- Sucralose Suppresses Food Intake
- Precision Metabolism: Hitting the Mark
- Feeding the Genome: In Silico Optimization of Diet...
- Integrative Physiology: At the Crossroads of Nutri...
- Beyond Digestion: The Pancreas Shapes Intestinal M...
- Matching Dietary Amino Acid Balance to the In Sili...
- Enhanced Protein Translation Underlies Improved Me...
- Systems Biology of Metabolism: A Driver for Develo...
- Ceramide Is Metabolized to Acylceramide and Stored...
- Should I Stay or Should I Go: A Clash of α-Cell Id...
- Dietary Fat Inflames CD4+ T Cell Memory in Obesity
- Insulin Signaling Regulates the FoxM1/PLK1/CENP-A ...
- Forecasting Fat Fibrosis
- Lip Sync: Gamma Rhythms Orchestrate Top-Down Contr...
- The Role of the Immune System in Metabolic Health ...
- Predicting Polygenic Obesity Using Genetic Informa...
- Metabolic Inputs into the Epigenome
- Epigenetic Mechanisms of Transmission of Metabolic...
- Orai1-Mediated Antimicrobial Secretion from Pancre...
- Islet encapsulation with polyphenol coatings decre...
- Exploration of the metal coordination region of co...
- A microengineered collagen scaffold for generating...
- Perivascular medical devices and drug delivery sys...
- Hepatic transcriptomic responses in mice exposed t...
- Early metal pollution in southwestern Europe: the ...
- How hard they hit? Perception, adaptation and publ...
- The key role of biogenic manganese oxides in enhan...
- Comparative study of adsorptive removal of Cr(VI) ...
- Determination of toxic metals, trace and essential...
- Progress, opportunities, and key fields for ground...
- Organized neurosurgery: Additional facts
- The element fluorine and its effects on human heal...
- A rare case of giant solitary calvarial plasmacyto...
- Two founders of Bombay Neurosciences: Professor Ga...
- A case of infectious intracranial dissecting aneurysm
- Hemichorea secondary to non-ketotic hyperglycemia ...
- Persistent trigeminal artery trunk giant aneurysm ...
- Deep tendon reflex: The background story of a simp...
- The 'reverse' evaluation!
- Description of coma and coma arousal therapy in Ca...
- Anaesthesia, chronic pain and brain connectivity
- Dyke–Davidoff–Masson syndrome
- Role of functional MRI in identifying network chan...
- Posterior inferior cerebellar artery susceptibilit...
- Traumatic brain injury in India: A big problem in ...
- Hyperdense lenticulostriate sign…or stroke followi...
- The role of systematic collection of epidemiologic...
- The cover page
- Quantitative research on traumatic brain injury in...
- Imaging biomarker correlates with oxidative stress...
- Impact of hyperglycemia on the efficacy of chemoth...
- Refining the indications for scapula tip in mandib...
- Influence of third molars in mandibular fractures....
- Erratum to
- Oesophageal cancer: which treatment is the easiest...
- Usefulness of self-report questionnaires for psych...
- Flexible heartbeat sensor for wearable device
- Chemical redox modulated fluorescence of nitrogen-...
- Simple, sensitive and label–free electrochemical d...
- Extensible multiplex real-time PCR for rapid bacte...
- A novel silver nanocluster in situ synthesized as ...
- Enhanced photocurrent production by the synergy of...
- Hybrid detection of target sequence DNA based on p...
- Can gene editing and silencing technologies play a...
- Correlation of Crtc1/3-Maml2 fusion status, grade ...
- Close surgical margin after conservative parotidec...
- Isotretinoin treatment for acne and risk of depres...
- Clinical similarity of biosimilar ABP 501 to adali...
- Nano-encapsulant of ascorbic acid-loaded apoferrit...
- Lipidomic analysis for carbonyl species derived fr...
- A simple and high-throughput method for determinat...
-
▼
Μαρ 10
(677)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Μαρτίου
(11966)
-
▼
Μαρ 10
(677)
- Application of Ultrasound-guided Pigtail Catheter ...
- City Noise Positively Correlates with Hearing Loss
- Application of Ultrasound-guided Pigtail Catheter ...
- Issue Information - Contents
- Cover Image
- Issue Information - Contents
- Cover Image
- Construct validity—Current issues and recommendati...
- Universal versus targeted additional contact preca...
- Gestational diabetes mellitus: an updated overview
- Contrast reaction training in US radiology residen...
- Response to Tulchinsky and Avram re: “Long-Term Ou...
- Response to Tulchinsky and Avram re: “Long-Term Ou...
- Vaccine Development
- Cell membrane integrity and revascularization: The...
- Skill-related physical fitness versus aerobic fitn...
- Radical Dissection of Greater Palatine Artery and ...
- Unilateral Pterional Polycraniosynostosis Treated ...
- Usefulness of self-report questionnaires for psych...
- Dynamics of progesterone and estrogen receptor alp...
- Confined polymerization: ARGET ATRP of MMA in the ...
- Effect of compositions of acceptor polymers on dar...
- Synergistic dielectric and semiconducting properti...
- Organogelation of self-assembling segmented poly(u...
- Effect of transfer agent, temperature and initial ...
- Corrigendum to “Is meditation always relaxing? Inv...
- The relationship of approach/avoidance motivation ...
- The Incidence and Health Care Resource Burden of t...
- Clinical Benefit in Response to Palbociclib Treatm...
- Sucralose Suppresses Food Intake
- Precision Metabolism: Hitting the Mark
- Feeding the Genome: In Silico Optimization of Diet...
- Integrative Physiology: At the Crossroads of Nutri...
- Beyond Digestion: The Pancreas Shapes Intestinal M...
- Matching Dietary Amino Acid Balance to the In Sili...
- Enhanced Protein Translation Underlies Improved Me...
- Systems Biology of Metabolism: A Driver for Develo...
- Ceramide Is Metabolized to Acylceramide and Stored...
- Should I Stay or Should I Go: A Clash of α-Cell Id...
- Dietary Fat Inflames CD4+ T Cell Memory in Obesity
- Insulin Signaling Regulates the FoxM1/PLK1/CENP-A ...
- Forecasting Fat Fibrosis
- Lip Sync: Gamma Rhythms Orchestrate Top-Down Contr...
- The Role of the Immune System in Metabolic Health ...
- Predicting Polygenic Obesity Using Genetic Informa...
- Metabolic Inputs into the Epigenome
- Epigenetic Mechanisms of Transmission of Metabolic...
- Orai1-Mediated Antimicrobial Secretion from Pancre...
- Islet encapsulation with polyphenol coatings decre...
- Exploration of the metal coordination region of co...
- A microengineered collagen scaffold for generating...
- Perivascular medical devices and drug delivery sys...
- Hepatic transcriptomic responses in mice exposed t...
- Early metal pollution in southwestern Europe: the ...
- How hard they hit? Perception, adaptation and publ...
- The key role of biogenic manganese oxides in enhan...
- Comparative study of adsorptive removal of Cr(VI) ...
- Determination of toxic metals, trace and essential...
- Progress, opportunities, and key fields for ground...
- Organized neurosurgery: Additional facts
- The element fluorine and its effects on human heal...
- A rare case of giant solitary calvarial plasmacyto...
- Two founders of Bombay Neurosciences: Professor Ga...
- A case of infectious intracranial dissecting aneurysm
- Hemichorea secondary to non-ketotic hyperglycemia ...
- Persistent trigeminal artery trunk giant aneurysm ...
- Deep tendon reflex: The background story of a simp...
- The 'reverse' evaluation!
- Description of coma and coma arousal therapy in Ca...
- Anaesthesia, chronic pain and brain connectivity
- Dyke–Davidoff–Masson syndrome
- Role of functional MRI in identifying network chan...
- Posterior inferior cerebellar artery susceptibilit...
- Traumatic brain injury in India: A big problem in ...
- Hyperdense lenticulostriate sign…or stroke followi...
- The role of systematic collection of epidemiologic...
- The cover page
- Quantitative research on traumatic brain injury in...
- Imaging biomarker correlates with oxidative stress...
- Impact of hyperglycemia on the efficacy of chemoth...
- Refining the indications for scapula tip in mandib...
- Influence of third molars in mandibular fractures....
- Erratum to
- Oesophageal cancer: which treatment is the easiest...
- Usefulness of self-report questionnaires for psych...
- Flexible heartbeat sensor for wearable device
- Chemical redox modulated fluorescence of nitrogen-...
- Simple, sensitive and label–free electrochemical d...
- Extensible multiplex real-time PCR for rapid bacte...
- A novel silver nanocluster in situ synthesized as ...
- Enhanced photocurrent production by the synergy of...
- Hybrid detection of target sequence DNA based on p...
- Can gene editing and silencing technologies play a...
- Correlation of Crtc1/3-Maml2 fusion status, grade ...
- Close surgical margin after conservative parotidec...
- Isotretinoin treatment for acne and risk of depres...
- Clinical similarity of biosimilar ABP 501 to adali...
- Nano-encapsulant of ascorbic acid-loaded apoferrit...
- Lipidomic analysis for carbonyl species derived fr...
- A simple and high-throughput method for determinat...
-
▼
Μαρ 10
(677)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου