Epigenetic regulation of RET receptor tyrosine kinase and non-coding RNAs in MTC

Publication date: Available online 15 March 2017
Source:Molecular and Cellular Endocrinology
Author(s): Lauren Jin Suk Joo, Jing Ting Zhao, Matti L. Gild, Anthony R. Glover, Stan B. Sidhu
Medullary thyroid carcinoma (MTC) is an aggressive and rare cancer with limited treatment options for metastatic disease. Due to this, there is a need for a better understanding of MTC biology in the hope of improved treatments. One area of improved understanding of cancer biology is epigenetics. Epigenetics is defined as cellular processes which alter gene expression independent of changes in the primary DNA sequence. These processes include modifications such as DNA methylation, microRNA deregulation and post-translational histone modifications, all of which have been implicated in tumorigenesis of MTC. Transcription of the main driver of MTC - the REarranged during Transfection (RET) proto-oncogene can also be modulated by epigenetic alterations. This review will present a review of MTC and its epigenetic links with a particular focus on targeting epigenetic mechanisms as novel therapeutic strategies.



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