Perinatal probiotics decreased eczema up to 10 years of age but at 5–10 years allergic rhino-conjunctivitis was increased

Abstract

Perinatal use of Lactobacillus GG (LGG) has been associated with fewer allergic diseases, mainly eczema in high-risk children at the age of two years [1,2], a phenomenon still seen at 6–9 years [2-5]. We reported earlier that in high-risk children pre- and postnatal use of a mixture of probiotics reduced the incidence of atopic eczema at two years of age, and during the first five years atopic eczema reduction was seen in Caesarean-delivered children but not in the whole cohort [1,6]. Mothers were recruited during pregnancy and randomized at 35 weeks of gestation to the probiotic or placebo group. Prematurity (less than 37 weeks of gestation), infants having major malformations or infants born as B-twins were excluded.

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