Plasma apolipoproteins and physical and cognitive health in very old individuals

Publication date: Available online 1 March 2017
Source:Neurobiology of Aging
Author(s): Julia Muenchhoff, Fei Song, Anne Poljak, John D. Crawford, Karen A. Mather, Nicole A. Kochan, Zixuan Yang, Julian N. Trollor, Simone Reppermund, Kate Maston, Adam Theobald, Susanne Kirchner-Adelhardt, John B. Kwok, Robyn L. Richmond, Mark McEvoy, John Attia, Peter W. Schofield, Henry Brodaty, Perminder S. Sachdev
Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease and longevity. We quantified seven apolipoproteins in plasma in 1067 individuals aged 56–105 using immunoassays and explored relationships with APOE polymorphism ε2/3/4, vascular health, frailty and cognition. ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH and ApoJ decreased from midlife, although ApoE and ApoJ had U-shaped trends. Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups. Apolipoprotein levels trended lower in APOE ε4 homo- and heterozygotes compared to non-carriers, with ApoE and ApoJ being significantly lower. Levels of all apolipoproteins except ApoH were higher in females. Sex- and age-related differences were apparent in the association of apolipoproteins with cognitive performance, as only women had significant negative associations of ApoB, ApoE, ApoH and ApoJ in mid-life, whereas associations at older age were non-significant or positive. Our findings suggest levels of some apolipoproteins, especially ApoE, are associated with lifespan and cognitive function in exceptionally long-lived individuals.



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