Structure, Synthesis and Biological Properties of the Pentacyclic Guanidinium Alkaloids

Publication date: Available online 12 March 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Yunlong Shi, Yasamin Moazami, Joshua G. Pierce
The pentacyclic guanidinium alkaloids (PGAs) are a family of marine natural products that possess a polycyclic guanidine-containing core and a long alkyl chain tethered spermidine-derived tail that is rarely observed in other natural products. These natural products exhibit potent activities on a wide range of organisms and therefore have attracted the attention of many synthetic chemists; however, the structure-activity relationships and mechanisms of action of PGAs remain largely elusive. Herein we summarize the structure, synthesis, toxicity and mechanisms of action of PGAs and highlight their potential as chemical probes and/or therapeutic leads.

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