The effect of local treatment modalities in patients with early-stage adenocarcinoma of the uterine cervix: a population-based analysis.

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The effect of local treatment modalities in patients with early-stage adenocarcinoma of the uterine cervix: a population-based analysis.

Int J Surg. 2017 Mar 13;:

Authors: Zhou J, Wu SG, Sun JY, Li FY, Lin HX, Chen DH, He ZY

Abstract
BACKGROUND: To determine the optimal local treatment modalities in stage IB-IIA adenocarcinoma (AC) of the uterine cervix and assess the impact of tumor size in the clinical outcomes.
METHODS: Patients with a primary diagnosis of stage IB-II cervix AC between 1988 and 2013 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Cox regression analyses were performed to analyze the effect of local treatment modalities on cause-specific survival (CSS) and overall survival (OS).
RESULTS: A total of 2,773 patients were identified. Of these, 1816, 765, and 162 patients received primary surgery, surgery and radiotherapy (RT), and primary RT, respectively. Local treatment modality was the independent prognostic factor for CSS and OS. Patients who received primary surgery had better CSS and OS, especially in patients with tumor size ≤ 4 cm. However, of those with tumor size > 4 cm, patients who underwent primary surgery showed significantly better survival; the survival of patients who underwent surgery and RT was not significantly different from those who underwent primary RT alone. The results were not influenced by the year before (1988-1999) and after (2000-2013) of the era of concurrent chemoradiation therapy.
CONCLUSIONS: Surgery remains the optimal local treatment modality in patients with early stage AC.

PMID: 28302450 [PubMed - as supplied by publisher]

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