Publication date: Available online 18 March 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Habiba Al Safar, Sarah El Hajj Chehadeh, Laila Abdel-Wareth, Afrozul Haq, Herbert F. Jelinek, Gehad ElGhazali, Fatme Al Anouti
At a prevalence rate close to 19.5%, the UAE has one of the highest rates of Type 2 Diabetes Mellitus (T2DM) in the world. Genome wide association studies (GWAS) have led to the identification of several genetic variants that are associated with T2DM. Recently, genes involved in vitamin D metabolism have gained interest because of the association between vitamin D deficiency (VDD) and increased risk for T2DM. Among these, the Vitamin D receptor (VDR) gene is a good candidate for T2DM susceptibility. The aim of this study was to investigate the association between VDR polymorphisms and T2DM among a representative sample of the Emirati population. In this cross sectional study, two hundred and sixty four patients with T2DM and ninety-one healthy controls were enrolled. The study population was genotyped for the three VDR gene mutations, TaqI (rs731236), FokI (rs2228570) and BsmI (rs1544410). VDR alleles and haplotypes were compared between patients and their healthy controls. The mean age of the T2DM cohort was 60±11.59years and 48.21±12.17years for the healthy controls. The G-allele and GG genotype of rs2228570 and T-allele and TT genotype of rs1544410 SNPs were associated with T2DM. In regards to T2DM-related metabolic complications, the AG and GG genotypes of rs731236 were significantly associated with higher total cholesterol (p=0.011) and LDL-cholesterol (p=0.009) levels in the patients with T2DM. In contrast, the CT genotype of rs1544410 was significantly associated with lower BMI (p=0.031) and the TT genotype was associated with lower LDL-cholesterol level (p=0.007). The frequency of AAT and GGC haplotypes was also different between groups (p=0.014; p=0.032, respectively), implying that these haplotypes of the VDR gene are associated with the susceptibility to T2DM in the Emirati population. To conclude, an association between SNPs in the VDR gene (except for rs731236) and T2DM per se was demonstrated. The rs731236 variant was shown to be associated with high cholesterol and LDL-cholesterol levels in T2DM patients, while rs1544410 was associated with lower BMI and lower LDL cholesterol levels. Our results imply that alleles and haploypes of the VDR gene are associated with the susceptibility to T2DM in the Emirati population.
http://ift.tt/2nQ1wFp
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Σάββατο 18 Μαρτίου 2017
Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus
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- Spatio-temporal patterns of event-related potentia...
- 3T Hippocampal Glutamate-Glutamine Complex Reflect...
- Genetic or pharmacological activation of the Droso...
- New concepts of personalized therapy in salivary g...
- Dosimetric comparison between treatment plans of p...
- A Modified Dual-plane Technique Using the Serratus...
- Dual lanthanide-doped complexes: the development o...
- Absence of functional fetal regulatory T cells in ...
- C3 nephritic factors: a changing landscape
- Rape myth acceptance in convicted rapists: A syste...
- Alcohol abuse, personality disorders, and aggressi...
- Ventricular wall biomaterial injection therapy aft...
- Biomaterials for intervertebral disc regeneration ...
- Croconaine nanoparticles with enhanced tumor accum...
- Long-term bioavailability of redox nanoparticles e...
- Changes in health-related quality of life of oral ...
- Dexamethasone injection into the pterygomandibular...
- Effect of passive smoking on auditory temporal res...
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- Electromyographic ratio of masseter and anterior t...
- Endoscopic management of bilateral vocal fold para...
- Anterior open bite correction by Le Fort I osteoto...
- Reply
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- Relationship Between Laryngeal Electromyography an...
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- Editorial Board
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- Difference of Type 3 secretion system (T3SS) effec...
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- Rupture of the extracranial carotid artery caused ...
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- A case of desmoid tumor co-existing with recurrent...
- Editorial Board
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- Unusual site of Rathke's cleft cyst: A case report...
- Intracranial hemorrhage from giant aneurysm in pre...
- Spontaneous extradural and subgaleal hematoma: A r...
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