Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

Publication date: 18 April 2017
Source:Immunity, Volume 46, Issue 4
Author(s): Ramon I. Klein Geltink, David O'Sullivan, Erika L. Pearce
T cell activation and proliferation critical for protective immunity depend on appropriate rewiring of cellular metabolism. In this issue of Immunity, Mak et al. (2017) show that the antioxidant gluthathione (GSH) controls reactive oxygen species (ROS)-dependent engagement of metabolic signaling pathways that lead to protective T cell responses.

Teaser

T cell activation and proliferation critical for protective immunity depend on appropriate rewiring of cellular metabolism. In this issue of Immunity, Mak et al. (2017) show that the antioxidant gluthathione (GSH) controls reactive oxygen species (ROS)-dependent engagement of metabolic signaling pathways that lead to protective T cell responses.


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