Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

Publication date: 18 April 2017
Source:Immunity, Volume 46, Issue 4
Author(s): Janna Krueger, Christopher E. Rudd
The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue of Science, Hui et al. (2017) and Kamphorst et al. (2017) now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.

Teaser

The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue of Science, Hui et al. (2017) and Kamphorst et al. (2017) now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.


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