Evaluation of bioabsorbable multiamino acid copolymer/nano- hydroxyapatite/calcium sulphate cage in a goat spine model.

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Evaluation of bioabsorbable multiamino acid copolymer/nano- hydroxyapatite/calcium sulphate cage in a goat spine model.

World Neurosurg. 2017 Apr 10;:

Authors: Ren C, Song Y, Xue Y, Yang X, Zhou C

Abstract
BACKGROUND: Recently, polylactide is the most popular material used to made bioabsorbable cages, but too fast degradation and osteolysis around the cage have been reported in the literature. This study evaluated the fusion effect, biomechanical stability and histological characteristics of a novel bioabsorbable multi-amino acid copolymer/nano-hydroxyapatite/calcium sulphate (MAACP/n-HA/CS) interbody cage in a goat model of anterior cervical discectomy and fusion (ACDF).
METHODS: A total of 24 goats underwent C3/C4 discectomy and fusion with three groups of intervertebral implants: MAACP/n-HA/CS cage group (n = 8), titanium cage group (n = 8) and autologous tricortical iliac crest bone group (n = 8). Disc space height (DSH) and lordosis angle (LA) were measured pre- and post-operatively and after 4, 12 and 24 weeks. Range of motion (ROM) was evaluated through biomechanical testing. Histological analysis was performed to evaluate fusion status and to detect any foreign body reactions associated with the bioabsorbable cages.
RESULTS: At 12 weeks and 24 weeks, DSH in MAACP/n-HA/CS cage group was higher than that of titanium cage group and tricortical iliac crest group (P < 0.05). LA in MAACP/n-HA/CS cage group and titanium cage group were lower than that of tricortical iliac crest group (p < 0.05). Biomechanical test showed that ROM did not differ significantly between MAACP/n-HA/CS cage group and titanium cage group, whereas the value of ROM in bone graft group was the largest. Histologic evaluation showed a better interbody fusion in the MAACP/n-HA/CS cage group than in the other two groups. MAACP/n-HA/CS cage surface degraded and was absorbed at 24 weeks. All MAACP/n-HA/CS cages showed excellent biocompatibility.
CONCLUSIONS: MAACP/n-HA/CS cage can provide good fusion effect, enough biomechanical stability and combining closely with the surrounding bone.

PMID: 28408260 [PubMed - as supplied by publisher]

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