Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Σάββατο 15 Απριλίου 2017

Pediatric basal ganglia region tumors: clinical and radiological features correlated with histopathological findings.

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Pediatric basal ganglia region tumors: clinical and radiological features correlated with histopathological findings.

World Neurosurg. 2017 Apr 10;:

Authors: Fu W, Ju Y, Zhang S, You C

Abstract
PURPOSE: To summarize the clinical and radiological features of pediatric basal ganglia region tumors (PBGRT) in correlation with their histopathological findings to reduce inappropriate surgery and identify tumors that can benefit from maximal safe resection.
METHODS: The records of 35 children with PBGRT treated in our hospital from December 2011 to December 2015 were retrospectively analyzed. The clinical and radiological features of these tumors were summarized in correlated with their histopathological diagnosis.
RESULTS: Our series included 15 astrocytomas and 11 germ cell tumors (GCT). Basal ganglia astrocytomas were characterized by various clinical presentations and ill-circumscribed mass with the involvement of surrounding structures upon neuroimaging and mostly occurred in the first decade of life (n = 10, 66.7%). Basal ganglia GCT mostly occurred in the second decade of life (n = 8, 72.7%) with hemiparesis as the most common symptom (n = 9, 81.8%). The tumors were predominantly located in the caput of caudate nucleus (n = 8, 72.7%) with hemiatrophy as the typical sign (n = 8, 72.7%). Occasionally, other tumors could also occur in this region, including primitive neuroectodermal tumor (n=1), atypical teratoid/rhabdoid tumor (n=1), anaplastic ependymoma (n=1), lymphoma (n=1), extraventricular neurocytoma (n=1), gangliogliomas (n=2), oligodendroglioma (n=1), and dysembryoplastic neuroepithelial tumor (n=1).
CONCLUSION: Astrocytoma and GCT are the most common PBGRT. Low-grade astrocytomas could benefit from maximal surgical resection while GCT merit neoadjuvant chemoradiation therapy followed by second-look surgery. We advocate routine testing of tumor markers and analysis of their clinical and radiological features to optimize the therapeutic strategy.

PMID: 28408259 [PubMed - as supplied by publisher]



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