Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis.

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Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis.

J Drugs Dermatol. 2017 Apr 01;16(4):372-377

Authors: Wu JJ, Gilbert KE, Batech M, Manalo IF, Towner WJ, Raposo RA, Nixon DF, Liao W

Abstract
<p>BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients.</p> <p>OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis.</p> <p>METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database.</p> <p>RESULTS: We identified 101 HIV-positive psoriasis cases; 19 met inclusion criteria and were matched with 3-5 control patients; 94 total patients were analyzed. The mean age was 41.4 (12.07) years and 83% were male. Overall, the median log of the viral load of cases was slightly higher than controls (4.3 vs 4.2; P less than 0.01).</p> <p>CONCLUSIONS: The serum viral load set point of patients with HIV and psoriasis was slightly higher than the viral load set point of HIV patients without psoriasis.</p> <p><em>J Drugs Dermatol. 2017;16(4):372-377.</em></p>.

PMID: 28403272 [PubMed - in process]

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