Immunotherapies in sarcoma: Updates and future perspectives.

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Immunotherapies in sarcoma: Updates and future perspectives.

World J Clin Oncol. 2017 Apr 10;8(2):145-150

Authors: Ghosn M, El Rassy E, Kourie HR

Abstract
Sarcomas are malignant tumors that are characterized by a wide diversity of subtypes with various cytogenetic profiles. Despite major treatment breakthroughs, standard treatment modalities combining chemotherapy, radiotherapy, and surgery failed to improve overall survival. Therefore, high expectations are foreseen with immunotherapy upon its maturation and better understanding of its mechanism of action. This paper presents a targeted review of the published data and ongoing clinical trials in immunotherapies of sarcomas, mainly adoptive cell therapies, cancer vaccines and immune checkpoint inhibitors.

PMID: 28439495 [PubMed - in process]

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