Publication date: Available online 1 April 2017
Source:Pathology - Research and Practice
Author(s): Xuchen Zhang, Hongfa Zhu, Xiu Yang, Volkan N. Adsay, Dhanpat Jain
Pancreatic "acinar cell cystadenoma" (PACA) is a rare benign pancreatic cystic lesion showing acinar cell differentiation. The neoplastic nature of PACA has been questioned and its exact pathogenesis remains unclear. To investigate that acinar cell differentiation is a non-specific metaplastic phenomenon that can occur in pancreatic ductal system, especially when chronically inflamed and dilated, and doesn't necessarily imply an acinar cell neoplasm, we retrospectively analyzed cases diagnosed as PACA and cases with post-obstructive cystic dilatation of pancreatic ducts for acinar cell differentiation using immunohistochemistry for trypsin. The etiology of obstruction was microscopic periductal pancreatic neuroendocrine tumors (PanNET) and pancreatic ductal adenocarcinomas (PDAC). All cases of post-obstructive cystic dilatation showed multiple varying sized cysts distal to the obstruction with histologic findings virtually identical to PACAs. The cysts in both conditions were lined by a single layer of non-dysplastic flattened to columnar ductal-type epithelium with areas of acinar cell differentiation. Trypsin immunohistochemistry confirmed presence of acinar cell differentiation in all cases of post-obstructive cysts and PACAs. Our results suggest that acinar cell differentiation is common in post-obstructive cyst formation, and changes are identical to PACAs. These findings further support the notion that PACA is a benign non-neoplastic cystic lesion with acinar cell differentiation. The findings also suggest that in cases with histology resembling "PACA" or showing diffuse ductal cystic dilation, careful gross examination should be carried out for a proximal obstructive lesion, which can be subtle and easily be missed on initial examination.
http://ift.tt/2nu0BKK
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Απριλίου
(11636)
-
▼
Απρ 01
(347)
- Clinical and molecular findings in a Moroccan fami...
- Impact of ingredients on the elemental content of ...
- Clinical and cross-sectional imaging features of s...
- Benefits of subspecialty adherence after asthma ho...
- Effect of alfacalcidol on the pulmonary function o...
- Mimicker of hereditary angioedema: Idiopathic syst...
- Dual training in allergy/immunology and rheumatology
- Broader concepts of quality of life measurement, e...
- Diagnostic accuracy of confocal microscopy imaging...
- The Effect of Body Weight on the Efficacy and Safe...
- The Icatibant Outcome Survey: experience of heredi...
- Topical treatment of psoriasis: questionnaire resu...
- Clinical and molecular findings in a Moroccan fami...
- Fixed-Level Frequency Threshold Testing for Ototox...
- Realisation of voicing by French-speaking CI child...
- Validity of auditory perceptual assessment of velo...
- Relations between awareness of morphosyntactic str...
- Analogical reasoning in children with specific lan...
- Antipsychotic activity of embelin isolated from Em...
- Wip1 inhibition leads to severe pro-inflammatory p...
- Real-time detection of organic contamination event...
- Characteristics and impacts of trace elements in a...
- Sleep disturbances in obsessive-compulsive disorde...
- The Affective Tie That Binds: Examining the Contri...
- Harm expectancy violation during exposure therapy ...
- ACKNOWLEDGEMENT
- Reduced Inhibition within Layer IV of Sert Knockou...
- Different Effects of Sleep Deprivation and Torpor ...
- Positive and Negative Somatotopic BOLD Responses i...
- Cc2d1a Loss of Function Disrupts Functional and Mo...
- Cerebral Activation During Initial Motor Learning ...
- ADAM10-Initiated Release of Notch Intracellular Do...
- Heparan Sulfates Support Pyramidal Cell Excitabili...
- In Vivo Evidence of Reduced Integrity of the Gray–...
- Reduced Hippocampal Functional Connectivity During...
- Compensatory Actions of Ldb Adaptor Proteins Durin...
- Hippocampus and Prefrontal Cortex Predict Distinct...
- NKCC1-Mediated GABAergic Signaling Promotes Postna...
- Gradient COUP-TFI Expression Is Required for Funct...
- cAMP-Dependent Calcium Oscillations of Astrocytes:...
- Regulation of Cognitive Processing by Hippocampal ...
- Direct Recordings from Human Anterior Insula Revea...
- Whole Transcriptome Screening Reveals Myelination ...
- Asc-1 Transporter Regulation of Synaptic Activity ...
- Common Neural Representations for Visually Guided ...
- Morphological characteristics of external auditory...
- Clinical and audiological characteristics of 1000H...
- Social attention and autism symptoms in high funct...
- Morphological characteristics of external auditory...
- Clinical and audiological characteristics of 1000H...
- Zuckerkandl’s tubercle and its relationship to the...
- Rejuvenation of mucosal immunosenescence by adipos...
- Cover
- Important Announcement
- In This Issue
- Subscriptions
- Table of Contents
- Mesenchymal stem cell-derived extracellular vesicl...
- Inflammatory and anti-inflammatory states of adipo...
- The spleen is the site where mast cells are induce...
- Zuckerkandl’s tubercle and its relationship to the...
- RE: “AGE AND SEX DIFFERENCES IN BODY MASS INDEX AS...
- Correction of Selection Bias in Survey Data: Is th...
- Masters et al. Respond
- Editorial: Note About Inaccurate Results Published...
- Testing for Gene-Environment Interactions Using a ...
- Assessment of Confounders in Comparative Effective...
- THE AUTHORS REPLY
- Mode of Delivery and Asthma at School Age in 9 Eur...
- Conducting Privacy-Preserving Multivariable Propen...
- Chronic Noncommunicable Diseases in 6 Low- and Mid...
- Interactions Between Genome-Wide Significant Genet...
- Invited Commentary: Foreclosures and Health in a N...
- Beyond the Great Recession: Was the Foreclosure Cr...
- Downing et al. Respond to “Foreclosures and Health...
- Diet-Induced Overweight and Obesity and Periodonti...
- Observed and Expected Mortality in Cohort Studies
- Toward a Framework for Benefit-Risk Assessment in ...
- The Management of Esophagogastric Cancers Enters a...
- Effect of alfacalcidol on the pulmonary function o...
- Dual training in allergy/immunology and rheumatology
- Mimicker of hereditary angioedema: Idiopathic syst...
- Benefits of subspecialty adherence after asthma ho...
- Effect of alfacalcidol on the pulmonary function o...
- Dual training in allergy/immunology and rheumatology
- Mimicker of hereditary angioedema: Idiopathic syst...
- Benefits of subspecialty adherence after asthma ho...
- Clinical and audiological characteristics of 1000H...
- Morphological characteristics of external auditory...
- Specific Recruitment of Circulating Angiogenic Cel...
- Choose Your Cell Model Wisely: The In Vitro Nanone...
- Optical imaging and anticancer chemotherapy throug...
- 3D screening device for the evaluation of cell res...
- Long-term blood glucose monitoring with implanted ...
- Scales used to rate adult patients’ psycho-emotion...
- A three-dimensional planned osteotomy on the zygom...
- The role of wide local excision for the treatment ...
- Injection speed of spinal anaesthesia for Caesarea...
- Factors influencing postoperative pain following d...
- Reply to: Microwave Thermosphere™ Ablation in the ...
-
▼
Απρ 01
(347)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Σάββατο 1 Απριλίου 2017
Post-Obstructive Cyst Formation in Pancreas and Cystic Acinar Transformation: Are They Same?
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Απριλίου
(11636)
-
▼
Απρ 01
(347)
- Clinical and molecular findings in a Moroccan fami...
- Impact of ingredients on the elemental content of ...
- Clinical and cross-sectional imaging features of s...
- Benefits of subspecialty adherence after asthma ho...
- Effect of alfacalcidol on the pulmonary function o...
- Mimicker of hereditary angioedema: Idiopathic syst...
- Dual training in allergy/immunology and rheumatology
- Broader concepts of quality of life measurement, e...
- Diagnostic accuracy of confocal microscopy imaging...
- The Effect of Body Weight on the Efficacy and Safe...
- The Icatibant Outcome Survey: experience of heredi...
- Topical treatment of psoriasis: questionnaire resu...
- Clinical and molecular findings in a Moroccan fami...
- Fixed-Level Frequency Threshold Testing for Ototox...
- Realisation of voicing by French-speaking CI child...
- Validity of auditory perceptual assessment of velo...
- Relations between awareness of morphosyntactic str...
- Analogical reasoning in children with specific lan...
- Antipsychotic activity of embelin isolated from Em...
- Wip1 inhibition leads to severe pro-inflammatory p...
- Real-time detection of organic contamination event...
- Characteristics and impacts of trace elements in a...
- Sleep disturbances in obsessive-compulsive disorde...
- The Affective Tie That Binds: Examining the Contri...
- Harm expectancy violation during exposure therapy ...
- ACKNOWLEDGEMENT
- Reduced Inhibition within Layer IV of Sert Knockou...
- Different Effects of Sleep Deprivation and Torpor ...
- Positive and Negative Somatotopic BOLD Responses i...
- Cc2d1a Loss of Function Disrupts Functional and Mo...
- Cerebral Activation During Initial Motor Learning ...
- ADAM10-Initiated Release of Notch Intracellular Do...
- Heparan Sulfates Support Pyramidal Cell Excitabili...
- In Vivo Evidence of Reduced Integrity of the Gray–...
- Reduced Hippocampal Functional Connectivity During...
- Compensatory Actions of Ldb Adaptor Proteins Durin...
- Hippocampus and Prefrontal Cortex Predict Distinct...
- NKCC1-Mediated GABAergic Signaling Promotes Postna...
- Gradient COUP-TFI Expression Is Required for Funct...
- cAMP-Dependent Calcium Oscillations of Astrocytes:...
- Regulation of Cognitive Processing by Hippocampal ...
- Direct Recordings from Human Anterior Insula Revea...
- Whole Transcriptome Screening Reveals Myelination ...
- Asc-1 Transporter Regulation of Synaptic Activity ...
- Common Neural Representations for Visually Guided ...
- Morphological characteristics of external auditory...
- Clinical and audiological characteristics of 1000H...
- Social attention and autism symptoms in high funct...
- Morphological characteristics of external auditory...
- Clinical and audiological characteristics of 1000H...
- Zuckerkandl’s tubercle and its relationship to the...
- Rejuvenation of mucosal immunosenescence by adipos...
- Cover
- Important Announcement
- In This Issue
- Subscriptions
- Table of Contents
- Mesenchymal stem cell-derived extracellular vesicl...
- Inflammatory and anti-inflammatory states of adipo...
- The spleen is the site where mast cells are induce...
- Zuckerkandl’s tubercle and its relationship to the...
- RE: “AGE AND SEX DIFFERENCES IN BODY MASS INDEX AS...
- Correction of Selection Bias in Survey Data: Is th...
- Masters et al. Respond
- Editorial: Note About Inaccurate Results Published...
- Testing for Gene-Environment Interactions Using a ...
- Assessment of Confounders in Comparative Effective...
- THE AUTHORS REPLY
- Mode of Delivery and Asthma at School Age in 9 Eur...
- Conducting Privacy-Preserving Multivariable Propen...
- Chronic Noncommunicable Diseases in 6 Low- and Mid...
- Interactions Between Genome-Wide Significant Genet...
- Invited Commentary: Foreclosures and Health in a N...
- Beyond the Great Recession: Was the Foreclosure Cr...
- Downing et al. Respond to “Foreclosures and Health...
- Diet-Induced Overweight and Obesity and Periodonti...
- Observed and Expected Mortality in Cohort Studies
- Toward a Framework for Benefit-Risk Assessment in ...
- The Management of Esophagogastric Cancers Enters a...
- Effect of alfacalcidol on the pulmonary function o...
- Dual training in allergy/immunology and rheumatology
- Mimicker of hereditary angioedema: Idiopathic syst...
- Benefits of subspecialty adherence after asthma ho...
- Effect of alfacalcidol on the pulmonary function o...
- Dual training in allergy/immunology and rheumatology
- Mimicker of hereditary angioedema: Idiopathic syst...
- Benefits of subspecialty adherence after asthma ho...
- Clinical and audiological characteristics of 1000H...
- Morphological characteristics of external auditory...
- Specific Recruitment of Circulating Angiogenic Cel...
- Choose Your Cell Model Wisely: The In Vitro Nanone...
- Optical imaging and anticancer chemotherapy throug...
- 3D screening device for the evaluation of cell res...
- Long-term blood glucose monitoring with implanted ...
- Scales used to rate adult patients’ psycho-emotion...
- A three-dimensional planned osteotomy on the zygom...
- The role of wide local excision for the treatment ...
- Injection speed of spinal anaesthesia for Caesarea...
- Factors influencing postoperative pain following d...
- Reply to: Microwave Thermosphere™ Ablation in the ...
-
▼
Απρ 01
(347)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου