Statistical Concerns on Vismodegib for Basal Cell Carcinoma Meta-Analysis—Reply

In Reply Regarding our article "Hedgehog Pathway Inhibitor Therapy for Locally Advanced and Metastatic Basal Cell Carcinoma: A Systematic Review and Pooled Analysis of Interventional Studies," Dr Lima draws attention to our pooled analysis methodology and applies a methodology for meta-analysis, thereby identifying a difference in confidence intervals while noting a small difference in mean values. He appropriately illustrates that it is very important for both authors and readers to understand the complex approaches in these types of studies.

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