Comparison of pharyngocutaneous fistula closure with and without bacterial cellulose in a rat model

Publication date: Available online 6 May 2017
Source:Auris Nasus Larynx
Author(s): Berat Demir, Murat Sarı, Adem Binnetoglu, Ali Cemal Yumusakhuylu, Deniz Filinte, İshak Özel Tekin, Tekin Bağlam, Abdullah Çağlar Batman
ObjectiveThe present study aimed to compare the effects of bacterial cellulose used for closure of pharyngocutaneous fistulae, a complication of total laryngectomy, with those of primary sutures in a rat model.MethodsThirty female Sprague-Dawley underwent experimental pharyngoesophagotomy and were grouped depending on the material used for pharyngocutaneous fistula closure: group I, which received primary sutures alone, group II, which received bacterial cellulose alone; and group III, which received both. After 7 days, the rats were sacrificed. Pharyngocutaneous fistula development was assessed, the gross wound was inspected, and histological examination was conducted.ResultsPharyngocutaneous fistulae developed in 12 rats (41%) in all: 6 from group I (21%), 4 from group II (14%) and 2 from group III (7%).ConclusionFibroblast density and inflammatory cell infiltration were significantly greater in group III than group I. We concluded that bacterial cellulose may be useful for pharyngocutaneous fistula closure.



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