Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism.

Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism.

Arch Physiol Biochem. 2017 May 16;:1-4

Authors: Nakajima K, Oda E

Abstract
CONTEXT: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA).
OBJECTIVE: To investigate the association between ketonuria and LSA.
METHODS: We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25-79 years who underwent a health-screening checkup.
RESULTS: There was an inverse relationship between body mass index (BMI) and serum amylase. The lowest serum amylase was observed in obese subjects (BMI ≥ 25.0 kg/m(2)) with positive ketonuria. Logistic regression analysis showed that ketonuria was significantly associated with LSA (<50 IU/L), which was not altered by the adjustments for relevant confounders including age, sex, BMI, and HbA1c.
CONCLUSIONS: Current results suggest a relative unavailability of carbohydrates for energy production in individuals with LSA.

PMID: 28508677 [PubMed - as supplied by publisher]

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