Thick tumor capsule is a valuable risk factor for distant metastasis in follicular thyroid carcinoma.

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Thick tumor capsule is a valuable risk factor for distant metastasis in follicular thyroid carcinoma.

Auris Nasus Larynx. 2017 May 12;:

Authors: Shimbashi W, Sugitani I, Kawabata K, Mitani H, Toda K, Yamada K, Sato Y

Abstract
OBJECTIVE: While the biological behavior of follicular thyroid carcinoma (FTC) has been studied in great detail using clinical experience, few studies have investigated pre- or intraoperative factors related to the risk of distant metastasis (DM) among patients with FTC. The aim of this study was to analyze the characteristics of FTC with DM.
METHODS: This study retrospectively investigated 102 patients with FTC who underwent surgery between 1988 and 2013. We compared clinicopathological characteristics between FTC with and without DM.
RESULTS: Univariate analysis revealed nodal metastasis (p=0.045), serum thyroglobulin (Tg) at initial operation (≥1000ng/ml; p<0.0001), widely invasive appearance according to macroscopic findings (p<0.0001), thick tumor capsule (≥1mm; p<0.0001), vascular invasion (p=0.0003), extrathyroidal invasion (p=0.047), and venous tumor embolism (p=0.045) as significant risk factors for DM. Multivariate analysis conducted using pre- and intraoperative factors identified thick tumor capsule (≥1mm), serum Tg at initial operation (≥1000ng/ml), and macroscopically widely invasive appearance as risk factors independently associated with development of DM.
CONCLUSION: Patients with these risk factors should undergo total thyroidectomy and radioactive iodine ablation.

PMID: 28506522 [PubMed - as supplied by publisher]

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