A Higher Ratio of Estradiol to Testosterone is associated with Autoimmune Thyroid Disease in Males.

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A Higher Ratio of Estradiol to Testosterone is associated with Autoimmune Thyroid Disease in Males.

Thyroid. 2017 May 30;:

Authors: Chen Y, Chen Y, Xia F, Wang N, Chen C, Nie X, Li Q, Han B, Zhai H, Jiang B, Shen Z, Lu Y

Abstract
BACKGROUND: Autoimmune thyroid disease (AITD) is highly prevalent. Although AITD is less common in males, it is unclear whether estradiol (E2) combined with total testosterone (T) contributes to the prevalence of AITD. We evaluated the association between the E2/T ratio and the prevalence of AITD in males.
METHODS: The data were obtained from a cross-sectional population-based study, the SPECT-China study, 2014-2015. A total of 4109 males older than 18 years of age were enrolled in this study. Participants underwent several checkups, which included assays of serum E2, T, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) levels as well as thyroid ultrasonography (US). We defined AITD based on the presence of TPOAb and TgAb levels, and the presence of thyroid ultrasonography (US) findings.
RESULTS: Overall, the prevalence of positivity for TPOAb and/or TgAb [TPO/TgAb(+)] was 11.02%, and the positivity for TPOAb and/or TgAb together with US [TPO/TgAb(+) & US(+)] was 4.58%. The E2/T ratio levels were significantly higher in the TPO/TgAb(+) group and the TPO/TgAb(+) & US(+) group (7.91±8.03 vs. 7.19±10.30, P=0.003; 8.78±11.26 vs. 7.19±10.30, P=0.001) compared with the TPOAb and TgAb negative [TPO & TgAb(-)] group. The prevalence of TPO/TgAb(+) & US(+) significantly increased with an increasing E2/T ratio (P=0.013). Binary logistic analysis showed that increased E2/T ratio levels were associated with an increased risk of AITD[TPO/TgAb(+): odds ratio(OR) 1.35, P= 0.002; TPO/TgAb(+) & US(+): OR 1.48, P= 0.006]. Conclusions：AITD is highly prevalent in males in China. Higher E2/T ratios were significantly associated with AITD among males. Further studies will be needed to assess whether there is a causal relationship between E2/T ratios and AITD.

PMID: 28558486 [PubMed - as supplied by publisher]

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