Acute Liver Failure Caused by Primary Non-Hodgkin's Lymphoma of the Liver.

Related Articles

Acute Liver Failure Caused by Primary Non-Hodgkin's Lymphoma of the Liver.

Transplant Proc. 2016 Nov;48(9):3000-3002

Authors: Romacho López L, León Díaz FJ, Sánchez Pérez B, Pérez Daga JA, Fernández Aguilar JL, Montiel Casado MC, Aranda Narváez JM, Suárez Muñoz MA, Santoyo Santoyo J

Abstract
INTRODUCTION: Acute liver failure (ALF) is a rare syndrome involving maximum liver dysfunction. This disease is characterized by a less than 26-week history of coagulopathy (INR ≥1.5) and hepatic encephalopathy and generally occurs in patients without any previously known disease.
METHODS: We report the case of a healthy 25-year-old subject who presented with fulminant liver failure caused by a primary non-Hodgkin's lymphoma of the liver that required emergency liver transplantation. Diagnosis was based on pathologic confirmation of T-cell/histiocyte-rich large B-cell lymphoma and submassive hepatocyte necrosis. One year after surgery, the patient remains in complete remission.
CONCLUSIONS: Fulminant liver failure is a sudden-onset severe disease that can be caused by a primary non-Hodgkin's lymphoma of the liver, which accounts for <1% of extranodal lymphomas. The diagnosis of this rare disease demands high diagnostic suspicion, and progression can be prevented through liver transplantation.

PMID: 27932130 [PubMed - indexed for MEDLINE]

http://ift.tt/2hjamJq