Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group.

Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group.

Oncotarget. 2017 May 13;:

Authors: Kong T, Chen Y, Guo Y, Wei Y, Jin X, Xie T, Mu Y, Dong Q, Wen S, Zhou B, Zhang L, Shen C, Zhu B

Abstract
In the present study, we assessed the genetic diversities of the Chinese Kazak ethnic group on the basis of 30 well-chosen autosomal insertion and deletion loci and explored the genetic relationships between Kazak and 23 reference groups. We detected the level of the expected heterozygosity ranging from 0.3605 at HLD39 locus to 0.5000 at HLD136 locus and the observed heterozygosity ranging from 0.3548 at HLD39 locus to 0.5283 at HLD136 locus. The combined power of discrimination and the combined power of exclusion for all 30 loci in the studied Kazak group were 0.999999999999128 and 0.9945, respectively. The dataset generated in this study indicated the panel of 30 InDels was highly efficient in forensic individual identification but may not have enough power in paternity cases. The results of the interpopulation differentiations, PCA plots, phylogenetic trees and STRUCTURE analyses showed a close genetic affiliation between the Kazak and Uigur group.

PMID: 28562361 [PubMed - as supplied by publisher]

http://ift.tt/2qIR17Q