Characterization of Breast Masses in Digital Breast Tomosynthesis and Digital Mammograms

Publication date: Available online 21 June 2017
Source:Academic Radiology
Author(s): Heang-Ping Chan, Mark A. Helvie, Lubomir Hadjiiski, Deborah O. Jeffries, Katherine A. Klein, Colleen H. Neal, Mitra Noroozian, Chintana Paramagul, Marilyn A. Roubidoux
Rationale and ObjectivesThis study aimed to compare Breast Imaging Reporting and Data System (BI-RADS) assessment of lesions in two-view digital mammogram (DM) to two-view wide-angle digital breast tomosynthesis (DBT) without DM.Materials and MethodsWith Institutional Review Board approval and written informed consent, two-view DBTs were acquired from 134 subjects and the corresponding DMs were collected retrospectively. The study included 125 subjects with 61 malignant (size: 3.9–36.9 mm, median: 13.4 mm) and 81 benign lesions (size: 4.8–43.8 mm, median: 12.0 mm), and 9 normal subjects. The cases in the two modalities were read independently by six experienced Mammography Quality Standards Act radiologists in a fully crossed counterbalanced manner. The readers were blinded to the prevalence of malignant, benign, or normal cases and were asked to assess the lesions based on the BI-RADS lexicon. The ratings were analyzed by the receiver operating characteristic methodology.ResultsLesion conspicuity was significantly higher (P << .0001) and fewer lesion margins were considered obscured in DBT. The mean area under the receiver operating characteristic curve for the six readers increased significantly (P = .0001) from 0.783 (range: 0.723–0.886) for DM to 0.911 (range: 0.884–0.936) for DBT. Of the 366 ratings for malignant lesions, 343 on DBT and 278 on DM were rated as BI-RADS 4a and above. Of the 486 ratings for benign lesions, 220 on DBT and 206 on DM were rated as BI-RADS 4a and above. On average, 17.8% (65 of 366) more malignant lesions and 2.9% (14 of 486) more benign lesions would be recommended for biopsy using DBT. The inter-radiologist variability was reduced significantly.ConclusionWith DBT alone, the BI-RADS assessment of breast lesions and inter-radiologist reliability were significantly improved compared to DM.



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