Dapagliflozin for the treatment of type 1 diabetes mellitus.

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Dapagliflozin for the treatment of type 1 diabetes mellitus.

Expert Opin Investig Drugs. 2017 Jun 06;:

Authors: Pafili K, Maltezos E, Papanas N

Abstract
INTRODUCTION: In 2017, the management of type 1 diabetes mellitus (T1DM) remains intriguing for the clinician, who has to balance between adequate glycemic control and untoward events related to insulin up-titration. Thus, agents that will complement insulin actions and reduce adverse effects are highly welcome. Areas covered: In this review, the authors summarize results from studies on the sodium dapagliflozin glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin in T1DM. Expert opinion: In T1DM, dapagliflozin is associated with significant antihyperglycemic and metabolic properties, which are achieved with reduction or stabilization of insulin dose and with a very low trend for hypoglycemia. However, there is a lot to learn with respect to diabetic ketoacidosis (DKA), bone fractures and lower limb ischemia.

PMID: 28587531 [PubMed - as supplied by publisher]

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