Gene-by-environment interactions of the CLOCK, PEMT and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children

Modern technology may have desensitised the 'biological clock' to environmental cues, disrupting the appropriate co-ordination of metabolic processes. Susceptibility to misalignment of circadian rhythms may be partly genetically influenced and effects on sleep quality and duration could predispose to poorer health outcomes. Shorter sleep duration is associated with obesity traits, which may be due to more opportunity to eat and/or a shift of hormonal profiles promoting hunger. We hypothesised that increased sleep duration will offset susceptible genetic effects, resulting in reduced obesity risk.

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